A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment Publisher Pubmed

Farahmand Y¹ ; Tehrany PM² ; Nazari A³ ; Nava ZH⁴ ; Alsaffar MF⁵ ; Yazdani O⁶ ; Adili A⁷ ; Esbati R⁶ ; Ghafouri K¹

Show Affiliations

1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Faculty of Medicine, National University of Malaysia, Bani, Malaysia
3. Tehran University of Medical Sciences, Tehran, Iran
4. Mazandaran University of Medical Science, Sari, Iran
5. Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babil, Hillah, 51001, Iraq
6. Department of Medicine, Shahid Beheshti University, Tehran, Iran
7. Tabriz University of Medical Sciences, Tabriz, Iran

Source: Pathology Research and Practice Published:2023

Abstract

Pancreatic cancer is the fourth most common malignant tumor in the world, which has a high mortality rate due to high invasiveness, early metastases, lack of specific symptoms, and high invasiveness. Recent studies have shown that exosomes can be essential sources of biomarkers in pancreatic cancer. Over the past ten years, exosomes have been implicated in multiple trials to prevent the growth and metastasis of many cancers, including pancreatic cancer. Exosomes also play essential roles in immune evasion, invasion, metastasis, proliferation, apoptosis, drug resistance, and cancer stemness. Exosomes help cells communicate by carrying proteins and genetic material, such as non-coding RNAs, including mRNAs and microRNAs. This review examines the biological significance of exosomes in pancreatic cancer and their functions in tumor invasion, metastasis, treatment resistance, proliferation, stemness, and immune evasion. We also emphasize recent advances in our understanding of the main functions of exosomes in diagnosing and treating pancreatic cancer. © 2023 Elsevier GmbH

Related Docs

View other Related Docs

1. Paper-Based Biosensors As Point-Of-Care Diagnostic Devices for the Detection of Cancers: A Review of Innovative Techniques and Clinical Applications, Frontiers in Oncology (2023)

2. Exosomal Micrornas in Regulation of Tumor Cells Resistance to Apoptosis, Biochemistry and Biophysics Reports (2024)

3. Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications, Current Medicinal Chemistry (2021)

4. Extracellular Vesicles Biogenesis, Isolation, Manipulation and Genetic Engineering for Potential in Vitro and in Vivo Therapeutics: An Overview, Frontiers in Bioengineering and Biotechnology (2022)

5. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)

6. Texosome-Based Drug Delivery System for Cancer Therapy: From Past to Present, Cancer Biology and Medicine (2015)

7. Communication Between Stromal and Hematopoietic Stem Cell by Exosomes in Normal and Malignant Bone Marrow Niche, Biomedicine and Pharmacotherapy (2020)

8. Gastrointestinal Cancer Drug Resistance: The Role of Exosomal Mirnas, Molecular Biology Reports (2022)

Experts (# of related papers)

View all Related Experts

Hamid Reza Mirzaei (9)

Nima Rezaei (5)

Other Related Docs

9. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)

10. Tumor-Derived Exosomes: The Next Generation of Promising Cell-Free Vaccines in Cancer Immunotherapy, OncoImmunology (2020)

11. Exosomal Long Non-Coding Rnas: Novel Molecules in Gastrointestinal Cancers’ Progression and Diagnosis, Frontiers in Oncology (2022)

12. Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy, Frontiers in Immunology (2020)

13. Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?, Journal of Cellular Physiology (2017)

14. Prospect of Exosomal Circular Rnas in Breast Cancer: Presents and Future, Molecular Biology Reports (2022)

15. Small Extracellular Vesicle Tgf-Β in Cancer Progression and Immune Evasion, Cancer Gene Therapy (2023)

16. Glioma and Exosome, Letters in Applied NanoBioScience (2022)

17. The Emerging Role of Exosomal Mirnas As a Diagnostic and Therapeutic Biomarker in Mycobacterium Tuberculosis Infection, Molecular Medicine (2021)

18. Microrna-155 and Its Exosomal Form: Small Pieces in the Gastrointestinal Cancers Puzzle, Cell Biology and Toxicology (2024)

19. The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases, Molecular Neurobiology (2019)

20. Exosome Application in Treatment and Diagnosis of B-Cell Disorders: Leukemias, Multiple Sclerosis, and Arthritis Rheumatoid, Cellular and Molecular Biology Letters (2022)

21. Modifying Exosome Release in Cancer Therapy: How Can It Help?, Pharmacological Research (2018)

22. Mesenchymal Stem/Stromal Cell-Derived Exosomes in Regenerative Medicine and Cancer; Overview of Development, Challenges, and Opportunities, Stem Cell Research and Therapy (2021)

23. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)

24. Minimal Information for Studies of Extracellular Vesicles (Misev2023): From Basic to Advanced Approaches, Journal of Extracellular Vesicles (2024)

25. Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma, International Journal of Molecular Sciences (2020)

26. Extracellular Vesicles: Essential Agents in Critical Bone Defect Repair and Therapeutic Enhancement, Molecular Biology Reports (2025)

27. Improvement, Scaling-Up, and Downstream Analysis of Exosome Production, Critical Reviews in Biotechnology (2020)

28. Designer Exosomes: A New Platform for Biotechnology Therapeutics, BioDrugs (2020)

29. The Tumor Microenvironment's Gambit: Exosomal Pawns on the Board of Head and Neck Cancer, Biochimica et Biophysica Acta - Reviews on Cancer (2024)

30. The Role of Exosomes Contents on Genetic and Epigenetic Alterations of Recipient Cancer Cells, Iranian Journal of Basic Medical Sciences (2016)

31. Exosomes As a Novel Cell-Free Therapeutic Approach in Gastrointestinal Diseases, Journal of Cellular Physiology (2019)

32. Harnessing the Power of Exosomes for Diagnosis, Prognosis, and Treatment of Hematological Malignancies, Stem Cell Research and Therapy (2025)

33. Mesenchymal Stem Cell-Derived Exosomes: A New Therapeutic Approach to Osteoarthritis?, Stem Cell Research and Therapy (2019)

34. Application of Stem Cell-Derived Exosomes in Anterior Segment Eye Diseases: A Comprehensive Update Review, Ocular Surface (2025)

35. Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the Cns, International Journal of Molecular Sciences (2023)

36. Exosomal Micrornas Derived From Mesenchymal Stem Cells: Cell-To-Cell Messages, Cell Communication and Signaling (2020)

37. The Potential Role of Mir-1290 in Cancer Progression, Diagnosis, Prognosis, and Treatment: An Oncomir or Onco-Suppressor Microrna?, Journal of Cellular Biochemistry (2022)

38. Noncoding Ribonucleic Acids (Rnas) May Improve Response to Immunotherapy in Pancreatic Cancer, ACS Pharmacology and Translational Science (2024)

39. Validation of Common Reference Genes Stability in Exosomal Mrna-Isolated From Liver and Breast Cancer Cell Lines, Cell Biology International (2021)

40. Association Between Micrornas and Chemoresistance in Pancreatic Cancer: Current Knowledge, New Insights, and Forthcoming Perspectives, Pathology Research and Practice (2022)

41. The Extracellular Vesicles-Derived From Mesenchymal Stromal Cells: A New Therapeutic Option in Regenerative Medicine, Journal of Cellular Biochemistry (2018)

42. Emerging Roles of Exosomal Mirnas in Breast Cancer Drug Resistance, IUBMB Life (2019)

43. The Multifaceted Role of Extracellular Vesicles (Evs) in Colorectal Cancer: Metastasis, Immune Suppression, Therapy Resistance, and Autophagy Crosstalk, Journal of Translational Medicine (2024)

44. Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors, Epigenetics Insights (2020)

45. Exosomes, Synthesis Lectures on Biomedical Engineering (2022)

46. Exosomes and Cancer, Synthesis Lectures on Biomedical Engineering (2022)

47. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis, Journal of Neuroimmune Pharmacology (2025)

48. Tumor-Derived Exosomal Micrornas and Proteins As Modulators of Macrophage Function, Journal of Cellular Physiology (2019)

49. Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease, Cardiovascular Toxicology (2022)

50. Liquid Biopsy in Thyroid Cancer: New Insight, International Journal of Hematology-Oncology and Stem Cell Research (2018)

Style	Citing Format
MLA	Farahmand Y, et al.. "A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment." Pathology Research and Practice, vol. 245, no. , 2023, pp. -.
APA	Farahmand Y, Tehrany PM, Nazari A, Nava ZH, Alsaffar MF, Yazdani O, Adili A, Esbati R, Ghafouri K (2023). A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment. Pathology Research and Practice, 245(), -.
Chicago	Farahmand Y, Tehrany PM, Nazari A, Nava ZH, Alsaffar MF, Yazdani O, Adili A, Esbati R, Ghafouri K. "A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment." Pathology Research and Practice 245, no. (2023): -.
Harvard	Farahmand Y et al. (2023) 'A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment', Pathology Research and Practice, 245(), pp. -.
Vancouver	Farahmand Y, Tehrany PM, Nazari A, Nava ZH, Alsaffar MF, Yazdani O, et al.. A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment. Pathology Research and Practice. 2023;245():-.
BibTex	@article{ author = {Farahmand Y and Tehrany PM and Nazari A and Nava ZH and Alsaffar MF and Yazdani O and Adili A and Esbati R and Ghafouri K}, title = {A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment}, journal = {Pathology Research and Practice}, volume = {245}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Farahmand Y AU - Tehrany PM AU - Nazari A AU - Nava ZH AU - Alsaffar MF AU - Yazdani O AU - Adili A AU - Esbati R AU - Ghafouri K TI - A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment JO - Pathology Research and Practice VL - 245 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract