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Effect of Helicobacter Pylori–Induced Gastric Cancer on Gastrointestinal Microbiota: A Narrative Review Publisher



Heidary M1 ; Akrami S2 ; Madanipour T3 ; Shakib NH4 ; Mahdizade Ari M5 ; Beig M6 ; Khoshnood S7 ; Ghanavati R8 ; Bazdar M9
Authors
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Authors Affiliations
  1. 1. Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  2. 2. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
  7. 7. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
  8. 8. School of Medicine, Behbahan Faculty of Medical Sciences, Behbahan, Iran
  9. 9. School of Medicine, Razi Hospital, Ilam University of Medical Sciences, Ilam, Iran

Source: Frontiers in Oncology Published:2024


Abstract

Helicobacter pylori (H. pylori) infection is a typical microbial agent that interferes with the complex mechanisms of gastric homeostasis by disrupting the balance between the host gastric microbiota and mucosa-related factors, ultimately leading to inflammatory changes, dysbiosis, and gastric cancer (GC). We searched this field on the basis of PubMed, Google Scholar, Web of Science, and Scopus databases. Most studies show that H. pylori inhibits the colonization of other bacteria, resulting in a less variety of bacteria in the gastrointestinal (GI) tract. When comparing the patients with H. pylori–positive and H. pylori–negative GC, the composition of the gastric microbiome changes with increasing abundance of H. pylori (where present) in the gastritis stage, whereas, as the gastric carcinogenesis cascade progresses to GC, oral and intestinal-type pathogenic microbial strains predominate. H. pylori infection induces a premalignant milieu of atrophy and intestinal metaplasia, and the resulting change in gastric microbiota appears to play an important role in gastric carcinogenesis. The effect of H. pylori–induced GC on GI microbiota is discussed in this review. Copyright © 2025 Heidary, Akrami, Madanipour, Shakib, Mahdizade Ari, Beig, Khoshnood, Ghanavati and Bazdar.
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