Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Investigation of the Relationship Between Aspirin-Sensitivity and Poor Response to Medical Management in Nsaids-Exacerbated Respiratory Disease Patients With Sinonasal Polyposis Publisher



Nabavi M1 ; Arshi S1 ; Bemanian MH1 ; Fallahpour M1 ; Molatefi R2 ; Rekabi M3 ; Eslami N4 ; Ahmadian J5 ; Darabi K1 ; Sedighi G6 ; Moinfar Z7 ; Faraji F8 ; Khoshmirsafa M9 ; Shokri S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Allergy and Clinical Immunology Department, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Allergy and Clinical Immunology Department, Bo-Ali hospital, Ardabil University of Medical Sciences, Ardabil, Iran
  3. 3. Allergy and Clinical Immunology Department, Masih-Daneshvari hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Allergy and Clinical Immunology Department, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Allergy and Clinical Immunology Department, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Allergy and Clinical Immunology Department, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Community and Preventive Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Immunology, Iran University of Medical Sciences, Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2023


Abstract

Background: NSAID-exacerbated respiratory disease (N-ERD) is a highly heterogeneous disorder with various clinical symptoms. The aspirin challenge test is a gold standard method for its diagnosis, and there are still no reliable in vitro diagnostic biomarkers yet. Oral challenge tests are time-consuming and may be associated with a risk of severe systemic reactions. This study aimed to evaluate whether patients with poor responses to medical management are more susceptible to being aspirin-sensitive. Methods: In this cohort study, after CT scanning of all patients and subject selection, conventional medical treatment was started as follows and continued for three consecutive months: at first, saline nose wash twice per day, intranasal beclomethasone spray one puff in each nostril twice per day, montelukast 10 mg tablet once daily, a ten-day course of oral prednisolone starting with the dose of 25 mg per day and taper and discontinued thereafter. Sinonasal outcome test 22 (SNOT22) was used for the evaluation of symptom severity. Statistical analyses were performed with SPSS version 23, and data were analyzed using an independent samples T-test, paired T-test, and Receiver operating curve analysis Results: 25 males and 53 females were enrolled in this study, with an average age of 41.56 ± 11.74 years old (18-36). Aspirin challenge test results were positive in 29 (37.2%) patients. The average SNOT22 scores before the treatment were 52.97 ± 17.73 and 47.04 ± 18.30 in aspirin-sensitive and aspirin-tolerant patients, respectively, and decreased to 27.41 ± 16.61 and 24.88 ± 16.72 in aspirin-sensitive and aspirin-tolerant patients after the treatment, respectively. There was no significant difference in SNOT22 scores between the groups. Conclusion: The severity of symptoms before treatment and clinical improvement after treatment are not good predictors of N-ERD. © Iran University of Medical Sciences
Related Docs
1. Aspirin Sensitivity in Patients With Moderate to Severe Asthma, Iranian Journal of Allergy# Asthma and Immunology (2020)
2. Pharmacogenetic Tests to Predict the Efficacy of Aspirin Desensitization in Patients With Aspirin-Exacerbated Respiratory Diseases; Hla-Dqb302, Expert Review of Respiratory Medicine (2015)
3. Assessment of Quality of Life and the Risk of Obstructive Sleep Apnea in Individuals With Chronic Rhinosinusitis Who Are Candidate for Functional Endoscopic Sinus Surgery, Tanaffos (2021)
4. Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial, Clinical Immunology (2015)
5. Hla-Drb and Hla-Dq Genetic Variability in Patients With Aspirin-Exacerbated Respiratory Disease, American Journal of Rhinology and Allergy (2015)
Experts (# of related papers)
Ali Akbar Amirzargar (2)
Nima Rezaei (1)