Association of the Matrix Metalloproteinases (Mmps) Family Gene Polymorphisms and the Risk of Coronavirus Disease 2019 (Covid-19); Implications of Contribution for Development of Neurological Symptoms in the Covid-19 Patients Publisher Pubmed



Ramezani S¹ ; Ezzatifar F^{2, 3} ; Hojjatipour T⁴ ; Hemmatzadeh M⁵ ; Shabgah AG⁶ ; Navashenaq JG⁷ ; Aslani S⁸ ; Shomali N⁵ ; Arabi M⁹ ; Babaie F¹⁰ ; Jadidiniaragh F^{11, 12} ; Hosseinzadeh R⁸ ; Feizisani F¹³ ; Khodayar S¹⁴ Show All Authors Show Affiliations
Source: Molecular Biology Reports Published:2023

Abstract

Background: Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS). Methods: We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted. Results: The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs. Conclusion: MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.