Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu

Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza] Publisher Pubmed

Farbod M¹ ; Dastgheib SA² ; Asadian F³ ; Karimizarchi M^{4, 5} ; Sayad S⁶ ; Barahman M⁷ ; Kargar S⁸ ; Mazaheri M⁹ ; Neamatzadeh H^{9, 10} ; Mazaheri M⁹

Show Affiliations

1. Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3. Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
4. Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
5. Endometriosis Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
6. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
7. Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
8. Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
9. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
10. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
11. Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Klinicka Onkologie Published:2022

Abstract

Background: Previous studies have evaluated the association of IL-8 -251T>A and IL-18 -607C>A polymorphisms with a risk of breast cancer in diff erent populations, but the results remain inconsistent and inconclusive. Thus, we performed this meta-analysis to explore the associations. Methods: A comprehensive literature search in PubMed, EMBASE, Web of Science, Scopus, SciELO, SID, and CNKI for all eligible studies published up to October 1, 2020. The pooled odds ratios (ORs) with 95% confi dence intervals (CIs) were used to evaluate the intensity of associations. Results: A total of 12 case-control studies including seven studies with 2,370 cases and 2,314 controls on IL-8 -251T>A, and fi ve studies with 900 cases and 882 controls on IL-18 -607C>A polymorphism were selected. Pooled data showed that IL-8 -251T>A (AT vs. TT: OR= 1.187; 95% CI 1.038–1.356; P = 0.012) and IL-18 -607C>A polymorphisms (A vs. T: OR = 1.205; 95% CI 1.055–1.377; P = 0.006; AA vs. TT: OR = 1.379; 95% CI 1.056–1.802; P = 018; and AA vs. AT+TT: OR = 1.329; 95% CI 1.053–1.678; P = 0.017) were associated with increased risk of breast cancer in overall. Moreover, when the studies were stratifi ed by ethnicity, the IL-8 -251T>A was signifi cantly associated with breast cancer risk in Africans. Publication bias tests provide no evidence of presence of publication bias in a meta-analysis. Conclusion: This meta-analysis results revealed that the IL-8 -251T>A and IL-18 -607C>A polymorphisms are associated with susceptibility to breast cancer. However, further multicenter studies with larger sample sizes in diff erent ethnicities are required to make a better assessment of these associations. © 2022, Czech Medical Association J.E. Purkyne. All rights reserved.

2. Arsenic and Benzo[A]Pyrene Co-Exposure Effects on Mda-Mb-231 Cell Viability and Migration, Biological Trace Element Research (2024)

3. Immunogenetics of Cancer, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)

4. Association of Pon1, Lep and Lepr Polymorphisms With Susceptibility to Breast Cancer: A Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2021)

5. Association of Il-10-1082G>A,-819C>T And-592C>A Polymorphisms With Susceptibility to Asthma in Children: A Systematic Review and Meta-Analysis, European Annals of Allergy and Clinical Immunology (2022)

6. An Overview of the Role of Interleukin-8 in Colorectal Cancer, Cytokine (2020)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (2)

Ali Akbar Amirzargar (1)

Style	Citing Format
MLA	Farbod M, et al.. "Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]." Klinicka Onkologie, vol. 35, no. 3, 2022, pp. 181-189.
APA	Farbod M, Dastgheib SA, Asadian F, Karimizarchi M, Sayad S, Barahman M, Kargar S, Mazaheri M, Neamatzadeh H, Mazaheri M (2022). Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]. Klinicka Onkologie, 35(3), 181-189.
Chicago	Farbod M, Dastgheib SA, Asadian F, Karimizarchi M, Sayad S, Barahman M, Kargar S, Mazaheri M, Neamatzadeh H, Mazaheri M. "Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]." Klinicka Onkologie 35, no. 3 (2022): 181-189.
Harvard	Farbod M et al. (2022) 'Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]', Klinicka Onkologie, 35(3), pp. 181-189.
Vancouver	Farbod M, Dastgheib SA, Asadian F, Karimizarchi M, Sayad S, Barahman M, et al.. Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]. Klinicka Onkologie. 2022;35(3):181-189.
BibTex	@article{ author = {Farbod M and Dastgheib SA and Asadian F and Karimizarchi M and Sayad S and Barahman M and Kargar S and Mazaheri M and Neamatzadeh H and Mazaheri M}, title = {Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza]}, journal = {Klinicka Onkologie}, volume = {35}, number = {3}, pages = {181-189}, year = {2022} }
RIS	TY - JOUR AU - Farbod M AU - Dastgheib SA AU - Asadian F AU - Karimizarchi M AU - Sayad S AU - Barahman M AU - Kargar S AU - Mazaheri M AU - Neamatzadeh H AU - Mazaheri M TI - Association of Il-8 -251T>A and Il-18 -607C>A Polymorphisms With Susceptibility to Breast Cancer – a Meta-Analysis; [Souvislost Polymorfi Zmu Il-8 -251T>A a Il-18 -607C>A S Nachylnosti Ke Karcinomu Prsu – Metaanalyza] JO - Klinicka Onkologie VL - 35 IS - 3 SP - 181 EP - 189 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract