Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Polymorphisms of Atp-Binding Cassette, Sub-Family A, Member 4 (Rs560426 and Rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis Publisher



Imani MM1 ; Sadeghi M2, 3 ; Tadakamadla SK4 ; Bruhl A5, 6 ; Bahmani DS5, 6, 7, 8, 9 ; Taheri M10 ; Brand S5, 6, 7, 8, 11, 12
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran
  2. 2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran
  3. 3. Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran
  4. 4. School of Dentistry and Oral Health, Griffith University, Gold Coast, 4214, Australia
  5. 5. Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, Basel, 4002, Switzerland
  6. 6. Department of Clinical Research, University of Basel, Basel, 4031, Switzerland
  7. 7. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6719851115, Iran
  8. 8. Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran
  9. 9. Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, 35209, AL, United States
  10. 10. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 65167198721, Iran
  11. 11. Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, 4052, Switzerland
  12. 12. School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran

Source: Life Published:2021


Abstract

Background: A number of genes are associated with the incidence of non-syndromic cleft lip/palate (NSCL/P). Studies have shown a significant association between polymorphisms of ATP-binding cassette, sub-family A, member 4 (ABCA4) with the risk of NSCL/P. The present meta-analysis assessed the association between ABCA4 polymorphisms (rs560426 and rs481931) and the NSCL/P risk by reviewing case-control studies. Methods: Four databases (Scopus; Cochrane Library; Web of Science; and PubMed) were searched for articles published up to June 2020. The Review Manager 5.3 software was used to calculate the crude odds ratio (OR) and 95% confidence interval (CI). Both subgroup analyses for ethnicity and source of controls and a meta-regression related to publication year were conducted. Results: Of 94 retrieved studies, 12 were analyzed in this meta-analysis (2859 NSCL/P patients and 3792 controls for ABCA4 rs560426 polymorphism and 1333 NSCL/P patients and 1884 controls for ABCA4 rs481931 polymorphism). Overall, there was no significant association between both polymorphisms and the risk of NSCL/P. However, subgroup analysis demonstrated that there was a higher risk of NSCL/P for specific models: the allelic model (OR = 1.13; p = 0.03), the homozygote model (OR = 1.53; p = 0.04), and the recessive model (OR = 1.30; p = 0.03) in the Asian ethnicity for the rs560426 polymorphism. Conclusion: The findings confirmed that the NSCL/P risk was significantly associated with the G allele and GG genotype of rs560426 polymorphism but not for rs481931 polymorphism. There were no associations between both polymorphisms (rs560426 and rs481931) and the NSCL/P risk in those of European descent and the mixed ethnicities. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Related Docs
1. Association Between Ptch1 and Rad54b Single-Nucleotide Polymorphisms and Non-Syndromic Orofacial Clefts in the Northeast Population of Iran, Avicenna Journal of Medical Biotechnology (2022)
2. Stem Cell-Based Regenerative Approaches for the Treatment of Cleft Lip and Palate: A Comprehensive Review, Stem Cell Reviews and Reports (2024)
3. Prevalence, Trend, and Associated Risk Factors for Cleft Lip With/Without Cleft Palate: A National Study on Live Births From 2016 to 2021, BMC Oral Health (2024)
4. Systems Genetics of Nonsyndromic Orofacial Clefting Provides Insights Into Its Complex Aetiology, European Journal of Human Genetics (2019)
5. Identification of Two Novel Mutations in Abca4 Gene in a Patient With Stargardt Disease, Acta Medica Iranica (2023)
Experts (# of related papers)
Masomeh Mohebbi (1)
Nima Rezaei (1)