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Ocular Graft-Versus-Host Disease (Ogvhd): From a to Z Publisher Pubmed



Soleimani M1, 2 ; Mahdavi Sharif P1 ; Cheraqpour K1 ; Koganti R2 ; Masoumi A1 ; Baharnoori SM2 ; Salabati M3 ; Djalilian AR2
Authors
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Authors Affiliations
  1. 1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States
  3. 3. Department of Ophthalmology, Virginia Commonwealth University Health System, Richmond, VA, United States

Source: Survey of Ophthalmology Published:2023


Abstract

Allogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a high mortality rate. Patients can also develop chronic graft-versus-host disease (cGVHD), a more indolent yet afflicting condition that affects up to 70% of patients. Ocular involvement (oGVHD) is one of the most prevalent presentations of cGVHD and can manifest as dry eye disease, meibomian gland dysfunction, keratitis, and conjunctivitis. Early recognition of ocular involvement using regular clinical assessments as well as robust biomarkers can aid in better management and prevention. Currently, the therapeutic strategies for the management of cGVHD, and oGVHD in particular, have mainly focused on the control of symptoms. There is an unmet need for translating the preclinical and molecular understandings of oGVHD into clinical practice. Herein, we have comprehensively reviewed the pathophysiology, pathologic features, and clinical characteristics of oGVHD and summarized the therapeutic landscape available to combat it. We also discuss the direction of future research regarding a more directed delineation of pathophysiologic underpinnings of oGVHD and the development of preventive interventions. © 2023 Elsevier Inc.