Association of Il-17A Gene Polymorphism Rs2275913 With Rheumatoid Arthritis Susceptibility in Iranian Patients Publisher



M Khojasteh MOZHGAN ; R Mansori REZA ; A Dehghani ALI ; Mt Mahmoudi Mahdi T ; S Mazazarzadeh SAED ; E Babakhanzadeh EMAD
Source: Egyptian Journal of Medical Human Genetics Published:2025

Abstract

Background: Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods: We examined the genes IL17A and IL17F in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the IL17A gene, and 116 RA patients and 107 healthy individuals for the IL17F gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses. Results: There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P = < 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780). Conclusion: Based on this study, rs2275913 polymorphism of gene IL17A could contribute to the risk of rheumatoid arthritis in Iranian patients. © 2025 Elsevier B.V., All rights reserved.