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Engineering the Niche for Hair Regeneration — a Critical Review Publisher Pubmed



Nilforoushzadeh MA1 ; Zare M1 ; Zarrintaj P2 ; Alizadeh E3 ; Taghiabadi E1, 4 ; Heidarikharaji M1 ; Amirkhani MA1 ; Saeb MR5 ; Mozafari M6, 7, 8
Authors
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Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Science, Tehran, Iran
  2. 2. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  3. 3. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  5. 5. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran
  6. 6. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  7. 7. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2019


Abstract

Recent progress in hair follicle regeneration and alopecia treatment necessitates revisiting the concepts and approaches. In this sense, there is a need for shedding light on the clinical and surgical therapies benefitting from nanobiomedicine. From this perspective, this review attempts to recognize requirements upon which new hair therapies are grounded; to underline shortcomings and opportunities associated with recent advanced strategies for hair regeneration; and most critically to look over hair regeneration from nanomaterials and pluripotent stem cell standpoint. It is noteworthy that nanotechnology is able to illuminate a novel path for reprogramming cells and controlled differentiation to achieve the desired performance. Undoubtedly, this strategy needs further advancement and a lot of critical questions have yet to be answered. Herein, we introduce the salient features, the hurdles that must be overcome, the hopes, and practical constraints to engineer stem cell niches for hair follicle regeneration. © 2018 Elsevier Inc.
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