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Niosomal Formulation for Antibacterial Applications Publisher Pubmed



Mehrarya M1 ; Gharehchelou B1 ; Haghighi Poodeh S1 ; Jamshidifar E2 ; Karimifard S3 ; Farasati Far B4 ; Akbarzadeh I3 ; Seifalian A5
Authors
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Authors Affiliations
  1. 1. Protein Research Centre, Shahid Beheshti University, Tehran, Iran
  2. 2. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, Iran
  4. 4. Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
  5. 5. Nanotechnology and Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd.) London BioScience Innovation Centre, London, United Kingdom

Source: Journal of Drug Targeting Published:2022


Abstract

Infection is a disease that is mainly caused by different Gram-negative and Gram-positive bacteria. Treatment of infections requires a considerable amount of antibiotics, which can cause serious damage to the patient's body. Delivering the antibiotic only to the site of infection can prevent these destructive effects, such as the destruction of the normal intestinal flora. The drug delivery system through carriers will take antibiotics into a part of the body involved in the disease. Niosome nanoparticles, which have been made from non-ionic surfactants, have been emerging as ideal drug/antibiotics delivery vehicles. Recently, niosome formulations have been targeted to reduce toxicity and increase accumulation at the target site. Niosomes have performed well in the treatment of local infections, delivery of ocular drugs, and coating of orthopaedic bone/dental implants. This research aimed to highlight the molecular structure and physicochemical properties of niosomes and covered its manufacturing methodologies. Then we critically review the literature on niosomes for the mechanism of drug release, the carrier to deliver antibiotics, and its clinical effectiveness against bacterial infections. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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