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Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators Against Molecularly Characterized Fusarium Species Publisher Pubmed



Abastabar M1 ; Alhatmi AMS2, 3, 4 ; Moghaddam MV5 ; De Hoog GS2, 3 ; Haghani I1 ; Aghili SR1 ; Shokohi T1 ; Hedayati MT1 ; Ghazvini RD6 ; Kachuei R7 ; Rezaeimatehkolaei A8 ; Makimura K9, 10 ; Meis JF3, 11 ; Badalia H12
Authors
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Authors Affiliations
  1. 1. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands
  3. 3. Centre of Expertise in Mycology Radboud University Medical Centre, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
  4. 4. Ministry of Health, Directorate General of Health Services, Ibri, Oman
  5. 5. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Mycology, School of Medicine, Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  9. 9. Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan
  10. 10. Teikyo University Institute of Medical Mycology, Tokyo, Japan
  11. 11. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
  12. 12. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Antimicrobial Agents and Chemotherapy Published:2018


Abstract

A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species. Copyright © 2018 American Society for Microbiology. All Rights Reserved.