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Antioxidant, Antibacterial and Anticancer Properties of Phyto-Synthesised Artemisia Quttensis Podlech Extract Mediated Agnps Publisher Pubmed



Ghanbar F1 ; Mirzaie A2 ; Ashrafi F1 ; Noorbazargan H3 ; Jalali MD4 ; Salehi S5 ; Shandiz SAS2
Authors
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Authors Affiliations
  1. 1. Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
  2. 2. Young Researchers and Elite Club, East Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, Faculty of Basic Science, Young Researcher Club, Lahijan Branch, Islamic Azad University, Lahijan, Iran
  5. 5. Department of Phytochemistry and Essential Oils Technology, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran

Source: IET Nanobiotechnology Published:2017


Abstract

The focus of this study is on a rapid and cost-effective approach for the synthesis of silver nanoparticles (AgNPs) using Artemisia quttensis Podlech aerial parts extract and assessment of their antioxidant, antibacterial and anticancer activities. The prepared AgNPs were determined by ultraviolet-visible spectroscopy, X-ray diffraction, Fourier transform infra-red spectroscopy, transmission electron microscopy, scanning electron microscopy, energy-dispersive spectroscopy, and dynamic light scattering and zeta-potential analysis. The AgNPs and A. quttensis extract were evaluated for their antiradical scavenging activity by 2, 2-diphenyl, 1-picryl hydrazyl assay and anticancer activity against colon cancer (human colorectal adenocarcinoma cell line 29) compared with normal human embryonic kidney (HEK293) cells. Also, the prepared AgNPs were studied for its antibacterial activity. The AgNPs revealed a higher antioxidant activity compared with A. quttensis extract alone. The phytosynthesised AgNPs and A. quttensis extract showed a dose-response cytotoxicity effect against HT29 and HEK293 cells. As evidenced by Annexin V/propidium iodide staining, the number of apoptotic HT29 cells was significantly enhanced, following treatment with AgNPs as compared with untreated cells. Besides, the antibacterial property of the AgNPs indicated a significant effect against the selected pathogenic bacteria. These present obtained results show the potential applications of phytosynthesised AgNPs using A. quttensis aerial parts extract. © The Institution of Engineering and Technology 2016.
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