Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Micrornas in the Viral Infections Publisher Pubmed



Fani M1 ; Zandi M2 ; Rezayi M3, 4 ; Khodadad N1 ; Langari H3 ; Amiri I5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Science, Tehran, Iran
  3. 3. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
  6. 6. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam

Source: Current Pharmaceutical Design Published:2018


Abstract

MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. In fact, many of them act as an oncogene or tumor suppressor. These molecular structures participate in many physiological and pathological processes of the cell. The virus can also produce them for developing its pathogenic processes. It was initially thought that viruses without nuclear replication cycle such as Poxviridae and RNA viruses can not code miRNA, but recently, it has been proven that RNA viruses can also produce miRNA. The aim of this articles is to describe viral miRNAs biogenesis and their effects on cellular and viral genes. © 2018 Bentham Science Publishers.
Other Related Docs
10. Microrna a New Gate in Cancer and Human Disease: A Review, Journal of Biological Sciences (2017)
13. Tumor Suppressive Function of Microrna-192 in Acute Lymphoblastic Leukemia, Bosnian Journal of Basic Medical Sciences (2017)
19. Prostate Cancer and Noncoding Rnas: A Focus on Mirnas, Lncrnas, and Circrnas, Prostate Cancer: Molecular Events and Therapeutic Modalities (2024)