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Mesoporous Bioactive Glasses: Promising Platforms for Antibacterial Strategies Publisher Pubmed



Kargozar S1 ; Montazerian M2 ; Hamzehlou S3, 4 ; Kim HW5, 6, 7 ; Baino F8
Authors
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Authors Affiliations
  1. 1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 917794-8564, Mashhad, Iran
  2. 2. Center for Research, Technology and Education in Vitreous Materials (CeRTEV), Federal University of Sao Carlos, Sao Carlos, 13565-905, SP, Brazil
  3. 3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 14155-6447, Iran
  4. 4. Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, 31116, South Korea
  6. 6. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, South Korea
  7. 7. Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine Research Center, Dankook University, Cheonan, 31116, South Korea
  8. 8. Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, 10129, Italy

Source: Acta Biomaterialia Published:2018


Abstract

The control of bacterial infections is of particular importance in the field of tissue engineering. Recently, much attention has been addressed toward the use of mesoporous bioactive glasses (MBGs) for antibacterial strategies, primarily because of their capability of acting as carriers for the local release of antimicrobial agents. The incorporation of antibacterial metallic ions including silver (Ag+), zinc (Zn2+), copper (Cu+ and Cu2+), cerium (Ce3+ and Ce4+), and gallium (Ga3+) cations into the MBG structure and their controlled release is proposed as one of the most attractive strategies for inhibiting bacterial growth and reproduction. Moreover, the possibility of loading and delivering various antibacterial biomolecules (e.g., antibiotics) through the porous structure of MBGs makes them as ideal candidates for antibacterial applications. In this review, we aim to present a comprehensive evaluation of MBG potential regarding antibacterial activities. For this purpose, different types of antibacterial ion-doped and drug-loaded MBGs are introduced and discussed in the light of existing knowledge, along with the significant challenges ahead. Statement of significance: Prevention and treatment of infections is one of the today's greatest challenges in medical sciences, also considering the well-known issues related to increased bacterial resistance to antibiotics. The advent of mesoporous glasses led to the birth of a new class of multifunctional biomaterials acting as bioactive platforms for the local release of organic or inorganic agents eliciting an antimicrobial effect. This reviews summarizes the state of the art of MBGs in this field, highlighting the latest evolutions and the specific role played by metallic antimicrobial ions that can be incorporated in the glass composition and then properly released. Perspective for tissue engineering applications are also discussed to provide an up-to-date contribution that is useful to both experienced scientists and early-stage researchers. © 2018 Acta Materialia Inc.
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