Pdcd1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis



Mahmoudi M^{1, 2} ; Rezaiemanesh A^{1, 3} ; Harsini S^{4, 5} ; Salmaninejad A⁶ ; Poursani S¹ ; Bahrami T⁷ ; Ziaee V^{8, 9} ; Rezaei N^{3, 5, 6}
Source: Acta Medica Iranica Published:2017

Abstract

Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients with JIA in comparison with 202 healthy controls and evaluated the frequency of alleles, genotypes, and haplotypes of PDCD1 single-nucleotide polymorphisms (SNPs), comprising PD-1.1 G/A, PD1.3 G/A and PD-1.9 C/T, using PCR-RFLP method. Both the allelic and genotype frequencies of PD-1.1, PD-1.3 and PD-1.9 were similar in two groups of patients and controls. Moreover, no significant difference was observed between the two groups of patients and controls for GGC (PD-1.1 G, PD-1.3 G, PD-1.9 C), GAC (PD-1.1 G, PD-1.3 A, PD-1.9 C), and AGT (PD-1.1 A, PD-1.3 G, PD-1.9 T) haplotypes. Our results did not show any association between PDCD1 SNPs and the development of JIA in Iranian population. © 2017 Tehran University of Medical Sciences. All rights reserved.