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Effects of Vitamin A, C and E, or Omega-3 Fatty Acid Supplementation on the Level of Paraoxonase and Arylesterase Activity in Streptozotocin-Induced Diabetic Rats: An Investigation of Activities in Plasma, and Heart and Liver Homogenates Publisher Pubmed



Zarei M1 ; Fakher S1 ; Tabei SMB2 ; Javanbakht MH1 ; Derakhshanian H1 ; Farahbakhshfarsi P1 ; Sadeghi MR3 ; Mostafavi E4 ; Djalali M1
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Reproductive Endocrinology and Embryology, Avesina Research Institute, Iran
  4. 4. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran

Source: Singapore Medical Journal Published:2016


Abstract

INTRODUCTION This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus. METHODS A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured. RESULTS Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors. CONCLUSION Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications. © 2016, University of Sheffield. All rights reserved.
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