Effect of 8 Weeks of Hospital-Based Resistance Training Program on Tcd4+ Cell Count and Anthropometric Characteristic of Patients With Hiv in Tehran, Iran: A Randomized Controlled Trial Publisher Pubmed



Ghayomzadeh M^{1, 2} ; Seyedalinaghi S² ; Shamsi MM¹ ; Rezaei S¹ ; Earnest CP⁴ ; Akbarnejad S³ ; Taj L² ; Mohraz M² ; Navalta JW⁶ ; Ghasemi P¹ ; Voltarelli FA⁵ Show Affiliations
Source: Journal of Strength and Conditioning Research Published:2019

Abstract

Ghayomzadeh, M, SeyedAlinaghi, S, Shamsi, MM, Rezaei, S, Earnest, CP, Akbarnejad, S, Taj, L, Mohraz, M, Navalta, JW, Ghasemi, P, and Voltarelli, FA. Effect of 8 weeks of hospital-based resistance raining program on TCD4+ cell count and anthropometric characteristic of patients with HIV in Tehran, Iran: A randomized controlled trial. J Strength Cond Res 33(4): 1146-1155, 2019 - We examined the effects of an 8-W circuit resistance training (RES) program using elastic bands and body weight on TCD4+ cell counts and anthropometry in patients with HIV. Patients (N = 21) receiving antiretroviral therapy were randomly assigned to resistance training (RES; n = 14) or control (CON; n = 7) groups. RES (3/W) consisted of training with elastic bands and bodyweight training focusing on major muscle groups. CON received standard care. Statistical analyses were performed using general linear models adjusted for age, sex, length of infection, and respective baseline measures. The primary outcome was TCD4+, and secondary outcomes were anthropometry indices. Tertiary assessments explored Pearson correlations surrounding the relationship between changes in anthropometry and TCD4+. We observed significant increases in TCD4+ count accompanying RES training (105.50 cells·mm-3, 95% confidence interval [CI], 47.42-163.59), whereas CON significantly decreased (-41.01 cells·mm-3, 95% CI, -126.78 to 44.76). Significant between-group differences were noted (p < 0.02; n2 = 0.42). We also observed significant reductions in fat mass for RES (1.18 kg, 95% CI = 1.80 to -0.56) vs. increased fat mass for CON (1.21 kg, 95% CI, 0.31 to 2.11). Significant between-group differences were noted (p = 0.001, n2 = 0.64). Similar effects were noted for lean body mass. No significant changes were observed for body mass. Significant correlations were observed for fat mass (r = -0.699, p = 0.001) and lean mass (r = 0.553, p = 0.017), but not body mass (r = -0.390, p = 0.109) vs. changes in TCD4+. Our results suggest that the RES program used in this study is effective for improving TCD4+ status and body composition in patients with HIV. © 2019 National Strength and Conditioning Association. Unauthorized reproduction of this article is prohibited.