The Effect of an Oral Ginger Supplementation on Nf-Κb Concentration in Peripheral Blood Mononuclear Cells and Anthropomorphic Data of Patients With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Mohammadzadeh Honarvar N¹ ; Zarezadeh M¹ ; Khorshidi M² ; Makhdoomi Arzati M¹ ; Yekaninejad MS³ ; Abdollahi M⁴ ; Effatpanah M⁵ ; Hashemi R⁶ ; Saedisomeolia A¹ Show Affiliations
Source: Complementary Therapies in Medicine Published:2019

Abstract

Introduction: The complications of diabetes are extensive which can be caused by excessive oxidative stress, inflammation and impaired insulin system. Plant-sourced bioactive compounds can reduce inflammation and oxidative stress. The aim of present study was to determine the effect of ginger supplementation on diabetic complications. Methods: The present study is a randomized double blind clinical trial which is conducted with 48 diabetic patients. The participants were randomly divided into two intervention and placebo groups which were received 2 g ginger powder and 2 g wheat flour respectively for 10 weeks. Nuclear factor kappa B (NF-κB) concentration and anthropometric measurements were evaluated at the baseline and at the end of study. Results: The effect of ginger supplementation on hip circumference was marginal and there was no significant effect on BMI and waist circumference. Mean NF-κB p65 concentrations were reduced in ginger supplementation group, however, the amount was not statistically significant. Conclusion: Ginger supplementation had significant effects on anthropometric evaluations. Ginger supplementation decreased mean NF-κB concentration in comparison with placebo, however the significance level was marginal. In order to achieve reliable information, more researches should be complemented with uptake of other diagnostic tools. © 2018