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Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms Publisher Pubmed



Mohammadi S1, 2 ; Moosaie F1, 2 ; Aarabi MH1
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Molecular Neurobiology Published:2020


Abstract

Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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