Efficacy and Safety of Arbidol in Treatment of Patients With Covid-19 Infection: A Randomized Clinical Trial Publisher



Ghaderkhani S¹ ; Khaneshan AS¹ ; Salami A¹ ; Alavijeh PE² ; Kouchak HE² ; Khalili H² ; Asadollahiamin A¹ ; Seyedalinaghi S¹ ; Ahmadinejad Z³ ; Rasolinejad M² ; Hajiabdolbaghi M² ; Jafari S² ; Hasannezhad M¹ ; Seifi A² Show All Authors Show Affiliations
Source: Journal of Iranian Medical Council Published:2022

Abstract

Background: COVID-19 has led to the demand for finding effective antiviral agents. Preliminary experiments showed Umifenovir inhibit replication in vivo. There is limited data on the clinical efficacy of COVID-19-infected pneumonia. Therefore, we aimed to evaluate this medication based on clinical findings. Methods: The present study was designed to investigate the advantages and disadvantages of Umifenovir and compared to empirical treatments. For this purpose, multi-stage sampling was considered. 56 people who had mild-to-moderate symptoms without signs of pneumonia, were selected by accidental non-random sampling method and divided into two groups [(group A with Hydroxychloroquine (HCQ) and group B in combination with Umifenovir] by randomized block sampling (1:1). During the study, three patients left the case group. Their clinical signs and symptoms were evaluated on 3rd, 7th, and 14th day after taking these medicines in the disease course. The SPSS software was used for data analysis and the significance level was considered to be p<0.05. Results: On the seventh day after visiting the patients, there were statistically significant differences in recuperation dry cough (p=0.001), weakness (p=0.004), gastrointestinal symptoms (p=0.043) and shortness of breath (p=0.001) between the two groups so that group B patients (HCQ and Umifenovir) had a faster recovery. In patients treated with HCQ and Umifenovir compared to the control group, myalgia (p=0.03), gastrointestinal symptoms (p=0.047) and weakness (p=0.007) improved significantly earlier during the illness. Conclusion: Evaluation of the clinical findings in mild-to-moderate COVID-19 patients’ symptoms was performed and it was shown that recuperation was faster in the group who received both HCQ and Umifenovir. Copyright 2022, Journal of Iranian Medical Council. All rights reserved.