Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mesenchymal Stem Cell-Derived Exosomes for Covid-19 Therapy, Preclinical and Clinical Evidence Publisher



Kiaie N1, 2 ; Ghanavati SPM3 ; Miremadi SS4 ; Hadipour A5 ; Aghdam RM1
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Metallurgy & Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Stem Cell & Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Tarmim Ava Baran Company, Tehran, Iran

Source: International Journal of Stem Cells Published:2021


Abstract

Since the emergence of the novel coronavirus, named COVID-19, researchers are looking for a treatment to stop the evastating pandemic. During these efforts, mesenchymal stem cells (MSCs), the potential next generation of therapeutic methods with wide application for diseases, have successfully controlled cytokine storm following the virus infection. However, the use of MSCs has been limited due to the ethical issues, immunogenicity, and genetic modifications. Therefore, exosomes were introduced as a suitable substitute for the MSCs. In the case of COVID-19 treatment, both MSCs and several preclinical and clinical studies of exosomes for COVID-19 treatment. © 2021 by the Korean Society for Stem Cell Research
Related Docs
View other Related Docs
1. The Role of Mesenchymal Stromal Cells in Immune Modulation of Covid-19: Focus on Cytokine Storm, Stem Cell Research and Therapy (2020)
2. Therapeutic Role of Mesenchymal Stem Cell-Derived Exosomes in Respiratory Disease, Stem Cell Research and Therapy (2022)
3. Stem Cell Therapy Potency in Personalizing Severe Covid-19 Treatment, Stem Cell Reviews and Reports (2021)
4. Mesenchymal Stromal/Stem Cells (Mscs) and Msc-Derived Extracellular Vesicles in Covid-19-Induced Ards: Mechanisms of Action, Research Progress, Challenges, and Opportunities, International Immunopharmacology (2021)
5. The Extracellular Vesicles-Derived From Mesenchymal Stromal Cells: A New Therapeutic Option in Regenerative Medicine, Journal of Cellular Biochemistry (2018)
6. Mesenchymal Stem/Stromal Cell-Derived Exosomes in Regenerative Medicine and Cancer; Overview of Development, Challenges, and Opportunities, Stem Cell Research and Therapy (2021)
7. The Critical Role of Mesenchymal Stromal/Stem Cell Therapy in Covid-19 Patients: An Updated Review, Cell Biochemistry and Function (2021)
8. The Promising Approach of Mscs Therapy for Covid-19 Treatment, Cell and Tissue Banking (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (3)
Mohammad Vasei (2)
Other Related Docs
9. Mesenchymal Stem/Stromal Cells As a Valuable Source for the Treatment of Immune-Mediated Disorders, Stem Cell Research and Therapy (2021)
10. Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to Be Aware Of, Current Pharmaceutical Biotechnology (2021)
11. Application of Wharton Jelly-Derived Mesenchymal Stem Cells in Patients With Pulmonary Fibrosis, Stem Cell Research and Therapy (2022)
12. Mesenchymal Stem Cell-Based Therapy As a New Therapeutic Approach for Acute Inflammation, Life Sciences (2023)
13. Hypothesis for the Management and Treatment of the Covid-19-Induced Acute Respiratory Distress Syndrome and Lung Injury Using Mesenchymal Stem Cell-Derived Exosomes, Medical Hypotheses (2020)
14. Potential Therapeutic Options for Covid-19: An Update on Current Evidence, European Journal of Medical Research (2022)
15. Covid-19: A Systematic Review and Update on Prevention, Diagnosis, and Treatment, MedComm (2022)
16. Critical Roles of Cytokine Storm and Bacterial Infection in Patients With Covid-19: Therapeutic Potential of Mesenchymal Stem Cells, Inflammopharmacology (2023)
17. Nanomedicine “New Food for an Old Mouth”: Novel Approaches for the Treatment of Covid-19, Drug Delivery Letters (2023)
18. Determine the Most Common Clinical Symptoms in Covid-19 Patients: A Systematic Review and Meta-Analysis, Journal of Preventive Medicine and Hygiene (2020)
19. Interaction Between Mesenchymal Stromal Cell-Derived Extracellular Vesicles and Immune Cells by Distinct Protein Content, Journal of Cellular Physiology (2019)
20. Effect of Mesenchymal Stem Cells-Derived Exosomes on Tumor Microenvironment: Tumor Progression Versus Tumor Suppression, Journal of Cellular Physiology (2019)
21. An Overview of the Recent Findings of Cell-Based Therapies for the Treatment and Management of Covid-19, International Immunopharmacology (2021)
22. Potential Therapeutic Applications of Extracellular Vesicles in the Immunopathogenesis of Covid-19, Pathology Research and Practice (2023)
23. Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight, International Journal of Stem Cells (2021)
24. Mesenchymal Stem Cells Derived From Perinatal Tissues for Treatment of Critically Ill Covid-19-Induced Ards Patients: A Case Series, Stem Cell Research and Therapy (2021)
25. Safety and Efficacy Study of Allogeneic Human Menstrual Blood Stromal Cells Secretome to Treat Severe Covid-19 Patients: Clinical Trial Phase I & Ii, Stem Cell Research and Therapy (2022)
26. Exosomes: Friends or Foes in Microbial Infections?, Infectious Disorders - Drug Targets (2024)
27. Efficacy of Oseltamivir in the Treatment of Patients Infected With Covid-19, Annals of Medicine and Surgery (2022)
28. Covid-19 Pathology on Various Organs and Regenerative Medicine and Stem Cell-Based Interventions, Frontiers in Cell and Developmental Biology (2021)
29. A Paradigm Shift in Cell-Free Approach: The Emerging Role of Mscs-Derived Exosomes in Regenerative Medicine, Journal of Translational Medicine (2021)
30. Exosomes As a Novel Cell-Free Therapeutic Approach in Gastrointestinal Diseases, Journal of Cellular Physiology (2019)
31. The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy Via the Modulation of Inflammatory Milieu, Journal of Clinical Medicine (2019)
32. Regenerative Medicine in Covid-19 Treatment: Real Opportunities and Range of Promises, Stem Cell Reviews and Reports (2021)
33. Mesenchymal Stem Cell Therapies for Covid-19: Current Status and Mechanism of Action, Life Sciences (2020)
34. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)
35. Recent Advances in Passive Immunotherapies for Covid-19: The Evidence-Based Approaches and Clinical Trials, International Immunopharmacology (2022)
36. Immunoediting in Sars-Cov-2: Mutual Relationship Between the Virus and the Host, International Immunopharmacology (2022)
37. Orthopedic Trauma Surgeries in Covid-19 Pandemic; a Trauma Management Algorithm, Archives of Bone and Joint Surgery (2020)
38. Menstrual Blood-Derived Mesenchymal Stem Cell Therapy for Severe Covid-19 Patients, Current Stem Cell Research and Therapy (2024)
39. The Coronavirus Disease 2019 and Effect on Liver Function: A Hidden and Vital Interaction Beyond the Respiratory System, Reviews and Research in Medical Microbiology (2022)
40. Biochemical Parameters and Pathogenesis of Sars-Cov-2 Infection in Vital Organs: Covid-19 Outbreak in Iran, New Microbes and New Infections (2020)
41. Extracellular Vesicles Isolated From Mesenchymal Stem Cell (Mscs) Negatively Regulates Human T Cell Survival by Inducing Caspase Cascade and Inhibiting Anti-Apoptotic Proteins, Nanomedicine Research Journal (2022)
42. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
43. Novel Therapeutic Approaches for Treatment of Covid-19, Journal of Molecular Medicine (2020)
44. The Use of Mesenchymal Stem Cells in the Process of Treatment and Tissue Regeneration After Recovery in Patients With Covid-19, Gene (2021)
45. Development and Application of Mesenchymal Stem Cell-Derived Exosomes in Cartilage Tissue Repair, Journal of Military Medicine (2022)
46. Mesenchymal Stem Cell–Derived Exosome Efficacy and Safety in Musculoskeletal Tissues: State of the Art and Future Directions, Regenerative Engineering and Translational Medicine (2025)
47. Sars-Cov-2: Current Trends in Emerging Variants, Pathogenesis, Immune Responses, Potential Therapeutic, and Vaccine Development Strategies, International Immunopharmacology (2021)
48. Immunotherapy for Sars-Cov-2: Potential Opportunities, Expert Opinion on Biological Therapy (2020)
49. Pneumocystis Pneumonia in Covid-19 Patients: A Comprehensive Review, Heliyon (2023)