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Rescue Effect of Curcumin Against Copper Toxicity Publisher Pubmed



Maghool F1 ; Emami MH1 ; Alipour R2 ; Mohammadzadeh S1 ; Sereshki N1 ; Dehkordi SAE3 ; Fahim A1 ; Tayaraninajaran Z4, 5 ; Sheikh A6 ; Kesharwani P6, 7, 8 ; Sahebkar A9, 10, 11, 12
Authors

Source: Journal of Trace Elements in Medicine and Biology Published:2023


Abstract

Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives (i.e. diacetylcurcumin (DAC) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. The aforementioned properties have put curcumin on spotlight as a potential treatment for ailments such as, hepatic diseases, neurodegenerative diseases, metabolic syndrome, dyslipidemia, cardiovascular disease, auto-immune diseases, malignancies and conditions associated with metal overload. Copper is essential for major biological functions, however, an excess causes chronic ailments including neurodegenerative disorders. The fascinating approach of curcumin could alleviate such effect by forming a complex. Thus, this review aims to present available data on the effect of copper-curcumin interaction in various in vitro, ex-vivo in vivo, and clinical studies. © 2023 Elsevier GmbH
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