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The Effectiveness of Nano-Curcumin on Patients With Covid-19: A Systematic Review of Clinical Trials Publisher Pubmed

Summary: Nano-curcumin may ease COVID-19 symptoms like fever & cough, reduce hospital stays & boost immunity, study finds. #COVID19 #Nanomedicine

Shojaei M1 ; Foshati S2 ; Abdi M1 ; Askari G3, 4 ; Sukhorukov VN5 ; Bagherniya M3, 4 ; Sahebkar A6, 7, 8, 9
Authors

Source: Phytotherapy Research Published:2023


Abstract

The main aim of the current study was to summarize the findings of available clinical studies to assess nano-curcumin's influence on COVID patients. A comprehensive online search was performed in Scopus, PubMed, ISI Web of Science, and Google Scholar until March 2022 to identify trials that investigated the effects of nano-curcumin in patients with COVID-19. Eight studies comprising 569 patients were included in this review. Compared with placebo, nano-curcumin had no significant effect on C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6). However, gene expression of IL-6 and gene expression as well as secretion of interleukin-1 beta (IL-1β) significantly decreased following nano-curcumin intervention. Nano-curcumin had beneficial effects on fever, cough, chills, myalgia, and olfactory and taste disturbances. The duration of hospitalization and mortality rate were significantly lower in the nano-curcumin group compared with the control group. Lymphocyte count was significantly increased after curcumin supplementation. Nano-curcumin also had favorable effects on O2 saturation, sputum, chest pain, wheeze, and dyspnea in patients with COVID-19. No major adverse effects were reported in response to nano-curcumin supplementation. In summary, the results of this systematic review of clinical trials suggested that nano-curcumin supplementation has beneficial effects on inflammation, respiratory function, disease manifestations, and complications in patients with COVID-19 viral infection. © 2023 John Wiley & Sons Ltd.
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