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Curcumin-Piperine Co-Supplementation and Human Health: A Comprehensive Review of Preclinical and Clinical Studies Publisher Pubmed

Summary: A review found curcumin-piperine improves diabetes, inflammation, and stress, offering natural health benefits. #NaturalRemedies #Health

Heidari H1 ; Bagherniya M2 ; Majeed M3 ; Sathyapalan T4 ; Jamialahmadi T5, 6 ; Sahebkar A6, 7, 8, 9
Authors

Source: Phytotherapy Research Published:2023


Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement. © 2023 John Wiley & Sons Ltd.
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