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Curcumin-Piperine Co-Supplementation and Human Health: A Comprehensive Review of Preclinical and Clinical Studies Publisher Pubmed



Heidari H1 ; Bagherniya M2 ; Majeed M3 ; Sathyapalan T4 ; Jamialahmadi T5, 6 ; Sahebkar A6, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Sabinsa Corporation, East Windsor, NJ, United States
  4. 4. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  5. 5. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Medicine, The University of Western Australia, Perth, WA, Australia
  9. 9. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Phytotherapy Research Published:2023


Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement. © 2023 John Wiley & Sons Ltd.
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