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Effect of Nano-Curcumin on Various Diseases: A Comprehensive Review of Clinical Trials Publisher Pubmed



Hassanizadeh S1 ; Shojaei M1 ; Bagherniya M1, 2 ; Orekhov AN3, 4 ; Sahebkar A5, 6, 7
Authors
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Authors Affiliations
  1. 1. Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  4. 4. Institute for Atherosclerosis Research, Moscow, Russian Federation
  5. 5. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: BioFactors Published:2023


Abstract

The antioxidant, anti-inflammatory, and antibacterial properties of curcumin have made it a valuable herbal product for improving various disorders, such as COVID-19, cancer, depression, anxiety, osteoarthritis, migraine, and diabetes. Recent research has demonstrated that encapsulating curcumin in nanoparticles might improve its therapeutic effects and bioavailability. To our knowledge, the efficacy of nano-curcumin on different aspects of health and disease has not been summarized in a study. Therefore, this review aimed to evaluate nano-curcumin's efficacy in various diseases based on the findings of clinical trials. In order to review publications focusing on nanocurcumin's impact on various diseases, four databases were searched, including PubMed, Scopus, Web of Science, and Google Scholar. This review highlights the potential benefits of nano-curcumin in improving a wide range of human diseases including COVID-19, neurological disorders, chronic disease, oral diseases, osteoarthritis, metabolic syndrome, and other diseases, especially as an adjunct to standard therapy and a healthy lifestyle. © 2023 International Union of Biochemistry and Molecular Biology.
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