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Therapeutic Application of Multipotent Stem Cells Publisher Pubmed



Mirzaei H1 ; Sahebkar A2 ; Sichani LS3 ; Moridikia A4 ; Nazari S5 ; Nahand JS6 ; Salehi H7 ; Stenvang J8 ; Masoudifar A9 ; Mirzaei HR10 ; Jaafari MR11
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Faculty of Basic Science, Department of Genetic, University of Shahrekord, Shahrekord, Iran
  4. 4. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Science, Department of Biology, North Tehran Branch of Islamic Azad University, Tehran, Iran
  6. 6. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology, University of Copenhagen, Copenhagen, Denmark
  9. 9. Department of Molecular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECRR, Isfahan, Iran
  10. 10. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Cellular Physiology Published:2018


Abstract

Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and antiapoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications. © 2017 Wiley Periodicals, Inc.
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