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Anxiolytic Effects of Salvia Reuterana Boiss. on the Elevated Plus-Maze Model of Anxiety in Mice Publisher Pubmed



Rabbani M1 ; Sajjadi SE2 ; Jafarian A3 ; Vaseghi G1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Hezar Jerib Avenue, Iran
  2. 2. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Pharmaceutical Research Centre, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Ethnopharmacology Published:2005


Abstract

The anxiolytic and sedative effects of hydroalcoholic extract (HE) of Salvia reuterana Boiss. was evaluated in mice. The HE of Salvia reuterana (100 mg/kg), increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze. Spontaneous locomotor activity count measured in 15 min of the test was significantly decreased in animals pretreated with diazepam and 100 mg/kg of Salvia reuterana extract. Results of the present study provide support for the traditional usage of Salvia reuterana as a sedative and anxiolytic medicinal plant. © 2005 Elsevier Ireland Ltd. All rights reserved.
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