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Radiobiological Evaluation and Comparison of Treatment Plans in Two Methods of 3D Adaptive Radiation Therapy and Tomotherapy for Left Pendular Breast Cancer and the Risk of Pericarditis and Pneumonia; [ارزیابی و مقایسهی رادیوبیولوژیکی طرحهای درمان در دو روش پرتودرمانی تطبیقی سه بعدی و توموتراپی] Publisher



Karampournajafabadi M1 ; Jafari A1 ; Najafizade N2 ; Saeb M1 ; Shanei A1
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radiation Oncology, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2023


Abstract

Background: This study aimed to compare the tumor control probability (TCP) and the normal tissue complications probability (NTCP) of three-dimensional adaptive radiation therapy (3D-CRT) and tomotherapy for left pendular breast cancer using radiobiological models. Methods: The current study was conducted on 20 patients with left pendular breast cancer who underwent treatment planning using the treatment planning system for 3D-CRT and tomotherapy. A prescribed dose of 50 Gy was implemented for the planning target volume (PTV) in both 3D-CRT and tomotherapy designs. The Equivalent Uniform Dose (EUD) of the Niemierko model was used to estimate the tumor control probability (TCP) and the normal tissue complications probability (NTCP). Findings: According to the results, the average TCP values for 3D-CRT and tomotherapy plans were 99.07 ± 0.13 and 99.32 ± 0.09, respectively, which did not show a statistically significant difference. The NTCP values for the lung and heart were significantly lower in tomotherapy plans compared to 3D-CRT plans. Conclusion: From a radiobiological point of view, the results showed that 3D-CRT resulted in a lower NTCP for the ipsilateral lung. In contrast, for TCP calculations, tomotherapy plans showed higher values compared to 3D-CRT plans. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.
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