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Therapeutic Plasma Exchange May Adjust Il-6 and Tgf-Β Signals in Relapsed Ms Patients Peripheral Blood Publisher Pubmed



Jamshidian A1, 2 ; Abdnikfarjam B3 ; Khademi Z4 ; Shaygannejad V5 ; Salehi M6
Authors

Source: Journal of Clinical Apheresis Published:2020


Abstract

Objective: Effects of therapeutic plasma exchange (TPE) on immune cells and their cytokine production in MS, are unknown. Since interleukine-6 and tumor growth factor-β have critical roles in MS immunopathogenesis, the impacts of TPE on the expression of these cytokines and their receptors on the surface of CD4+ T lymphocytes, were investigated. Methods: Blood cells were obtained from 30 Relapsing-Remitting (RR) MS patients, before and after a complete TPE course. Cytokines mRNA and their receptor expression on the CD4+ T cells surface were assessed using real-time PCR and flowcytometry, respectively. Results: TPE reduced symptom severity (P =.01) and the relief was higher in males than in females (P =.039). TPE also increased TGF-β mRNA and decreased IL-6 receptor expressing cells frequency (P =.009 and P =.028, respectively). Moreover, the frequency of CD4+IL6R+ T cells was positively correlated with disease severity (P =.001). Conclusion: TPE impacts simultaneously on the TGF-β mRNA and IL-6 receptor expression, and this may be a mechanism of improvement in MS relapse symptoms induced by the TPE. © 2020 Wiley Periodicals, Inc.
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