Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase

Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase

Moshtaghie AA¹ ; Ani M¹ ; Soltani M¹

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1. Department of Biochemistry, School of Pharmacy, Isfahan University of Med. Sciences, Isfahan, Iran

Source: Indian Journal of Pharmacology Published:1995

Abstract

The present study was undertaken to investigate the effects of testosterone, 17-β-estradiol and castration on serum alkaline phosphatase isoenzymes in male rats. Daily administration of testosterone (2 mg/kg) for 15, 30 and 60 days increased serum total alkaline phosphatase activity by 9, 26 and 65 percent respectively. Estradiol administration (0.2 mg/kg) in the same periods led to the increase of 69, 67 and 68 percent. Enzyme fractionation on sephacryl S-300 revealed that the increase in alkaline phosphatase activity was due to the absolute elevation of low-molecular weight alkaline phosphatase isoenzyme. Castration or treatment with actinomycin-D puromycin of the animal diminished enzyme activity by 28-37 percent. The estradiol induced increase in enzyme activity had additive effect with puromycin or actinomycin D in the doses used.

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Style	Citing Format
MLA	Moshtaghie AA, Ani M, Soltani M. "Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase." Indian Journal of Pharmacology, vol. 27, no. 3, 1995, pp. 152-155.
APA	Moshtaghie AA, Ani M, Soltani M (1995). Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase. Indian Journal of Pharmacology, 27(3), 152-155.
Chicago	Moshtaghie AA, Ani M, Soltani M. "Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase." Indian Journal of Pharmacology 27, no. 3 (1995): 152-155.
Harvard	Moshtaghie AA, Ani M, Soltani M (1995) 'Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase', Indian Journal of Pharmacology, 27(3), pp. 152-155.
Vancouver	Moshtaghie AA, Ani M, Soltani M. Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase. Indian Journal of Pharmacology. 1995;27(3):152-155.
BibTex	@article{ author = {Moshtaghie AA and Ani M and Soltani M}, title = {Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase}, journal = {Indian Journal of Pharmacology}, volume = {27}, number = {3}, pages = {152-155}, year = {1995} }
RIS	TY - JOUR AU - Moshtaghie AA AU - Ani M AU - Soltani M TI - Study of the Effect of Steroid Hormones on Serum High- and Low-Molecular Weight Alkaline Phosphatase JO - Indian Journal of Pharmacology VL - 27 IS - 3 SP - 152 EP - 155 PY - 1995 ER -

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