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Pbmcs: A New Source of Diagnostic and Prognostic Biomarkers Publisher Pubmed



Mosallaei M1 ; Ehtesham N1 ; Rahimirad S1 ; Saghi M2 ; Vatandoost N1 ; Khosravi S1
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. AJA Cancer Epidemiology Research and Treatment Center (AJA-CERTC), AJA university of medical sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

There are various types of molecular biomarkers that are derived from distinct starting materials. Although many indirect biomarkers are found in blood, their detection remains a challenging issue because of the high degree of fragmentation, minute quantity and a vast amount of non-specific background. The present review points out the sensitivity and specificity of peripheral blood mononuclear cells (PBMCs) as an intact source of biomarkers in a variety of diseases. Multiple recent studies that have used PBMCs as a source of biomarkers reveal the alteration of mRNAs/microRNAs (miRNAs) signature and methylation profile in many kinds of disorders; for instance, dysregulation of mRNAs/miRNAs in schizophrenia, diabetes and different types of cancers and change in the methylation status of LINE-1 in neoplasms. In conclusion with a strong probability, PBMCs mimic conditions of some tissues which are in contact with them like the tumour cells, hence providing a non-invasive and suitable source of biomarkers. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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