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In-Vivo Evaluation of a Partially Resorbable Poly L-Lactic Acid/ Braided Bioactive Glass Fibers Reinforced Composite for Load Bearing Fracture Fixation Publisher Pubmed



Zargar Kharazi A1 ; Fathi MH2 ; Manshaei M3, 4 ; Razavi SM3
Authors
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Authors Affiliations
  1. 1. Biomaterials Nanotechnology and Tissue Engineering faculty, School of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  2. 2. Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  3. 3. School of Dentistry, Isfahan UnIversity of Medical Sciences, Isfahan, Iran
  4. 4. Department of Surgery, Islamic Azade University Shahrekord Branch, sharekord, Iran

Source: Journal of Materials Science: Materials in Medicine Published:2020


Abstract

Our previous studies have been focused on the design, optimization and manufacture of a partially resorbable composite bone plate consisting of a poly l-lactic acid matrix reinforced with braided fabrics bioactive glass fibers (PLLA/BG). In the present study, the response of the composite samples, the degradation rate, the inflammatory response, fibrous capsule formation and tissue-implant bonding to the in-vivo environment were assessed via implantation in the rabbit subcutaneous tissue. Despite the presence of both enzymatic degradation and hydrolysis processes within the body, the rate of the molecular weight loss as an indicator of degradation did not show a significant difference with the in-vitro conditions. It was predicted that strength loss would show the same trend since it was a consequence of molecular chain disruption and the loss of molecular weight. Inexistence of chronic inflammation, as confirmed by our previous results on the controlled degradation rate, also showed the maintenance of the physiological pH in the peripheral environment of the implant. Moreover, lack of the fibrous capsule tissue around the implant indicated that the implant was bioactive. In addition, given the composition of the bioactive glass fibers, that could be bonded to soft and hard tissues, tissue bonding with the PLLA/BG composite samples was also observed, thereby confirming the bioactivity and biocompatibility of the proposed bone plate. [Figure not available: see fulltext.]. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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