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In Vivo and in Vitro Evaluation of Poly (Lactide-Co-Glycolide)/Bioactive Glass Nanocomposite Coating Publisher



Mehdikhaninahrkhalaji M1 ; Fathi MH2 ; Mortazavi V3 ; Mousavi SB4 ; Hashemibeni B5 ; Razavi SM6 ; Akhavan A4 ; Haghighat A7
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Authors Affiliations
  1. 1. Biomaterials Group, Department of Biomedical Engineering, Semnan University, Semnan, Iran
  2. 2. Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  3. 3. Department of Operative Dentistry and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Torabinejad Dental Research Center, Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Oral and Maxillofacial Pathology and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Oral and Maxillofacial Surgery and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Advanced Materials Research Published:2014


Abstract

The aim of this study was to evaluate the interaction of bioactive and biodegradable poly (lactideco- glycolide)/bioactive glass (PBG) nanocomposite coating with bone and human adipose-derived stem cells (hASC) in vivo and in vitro, respectively. Sol-gel derived 58S bioactive glass (BG) nanoparticles and 50/50wt% poly (lactic acid)/poly (glycolic acid) (PLGA) were used to prepare the coating. The nanocomposite coating was characterized by SEM, XRD, and AFM. Mechanical stability of the prepared nanocomposite coating was studied during intramedullary implantation of coated Kirschner wires (k-wires) into rabbit tibiae. Titanium mini-screws coated with PBG nanocompoite coating was implanted intramedullary in rabbit tibia. Bone tissue interaction with the prapared nanocomposite coating was evaluated 30 and 60 days after surgery. The effect of PBG nanocomposite coating on the attachment and viability of human adipose-derived stem cells (hASCs) was investigated. Results showed that PBG nanocomposite coating remained stable on the K-wires with a minimum of 96% of the original coating mass. Tissue around the coated implants showed no adverse reactions to the coating. Woven and trabecular bone formation were observed around the coated samples with a minimum inflammatory reaction. The hASCs showed excellent attachment and viability on the PBG nanocomposite coating. It was concluded that PBG nanocomposite coating provides an ideal surface for bone formation and stem cells attachment and i t could be used as a candidate for coating the dental and orthopedic implants. © (2014) Trans Tech Publications, Switzerland.
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