Macroscopic Effect of Blue Light Cure on Wound Healing Process



Nilforoushzadeh MA^{1, 2} ; Changizi V³ ; Mardani H⁴ ; Kakanezhadian P⁵ ; Javadi FM⁵ ; Jaffary F^{1, 2} ; Haftbaradaran E² Show Affiliations
Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Wound healing is a complex process and a worldwide challenge. Some studies have suggested light cure as a modality to accelerate wound repair. It could induce fibroblast proliferation, increase collagen synthesis and activate cellular processes involved in expression of procollagen type I and III mRNA. This study was designed to assess macroscopic effect of halogen dental curing blue light on a full thickness open wound healing in NMRI mices. Methods: 40 male NMRI rats were divided into the control and treatment groups. Full thickness wound with 6 mm diameter was induced on the lower back of all mice under general anesthesia and sterile conditions. All mice of the treatment group were exposed daily to a halogen dental curing blue light with a wavelength of 420-500 nm, for 7 days. The diameter of the wound was measured in both treatment and control groups every 2 days up to day 14. Findings: There was a significant difference in wound diameter between control and treatment group at all measurements after day 3 (P ≤ 0.05). Conclusion: Previous studies have shown the efficacy of low level laser in wound healing, pain relief, increasing local blood supply, decreasing inflammation and bactericidal effect. The results of this study suggest improvement of full thickness wound healing by daily irradiation of halogen dental curing blue light with a wavelength 420-500 nm for 7 days.