Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms

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Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms Publisher Pubmed

Jamshidian A¹ ; Shaygannejad V² ; Pourazar A¹ ; Zarkeshesfahani SH^{1, 3} ; Gharagozloo M^{1, 4}

Source: Journal of Neuroimmunology Published:2013

Abstract

The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease. © 2013.

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Style	Citing Format
MLA	Jamshidian A, et al.. "Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms." Journal of Neuroimmunology, vol. 262, no. 1-2, 2013, pp. 106-112.
APA	Jamshidian A, Shaygannejad V, Pourazar A, Zarkeshesfahani SH, Gharagozloo M (2013). Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms. Journal of Neuroimmunology, 262(1-2), 106-112.
Chicago	Jamshidian A, Shaygannejad V, Pourazar A, Zarkeshesfahani SH, Gharagozloo M. "Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms." Journal of Neuroimmunology 262, no. 1-2 (2013): 106-112.
Harvard	Jamshidian A et al. (2013) 'Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms', Journal of Neuroimmunology, 262(1-2), pp. 106-112.
Vancouver	Jamshidian A, Shaygannejad V, Pourazar A, Zarkeshesfahani SH, Gharagozloo M. Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms. Journal of Neuroimmunology. 2013;262(1-2):106-112.
BibTex	@article{ author = {Jamshidian A and Shaygannejad V and Pourazar A and Zarkeshesfahani SH and Gharagozloo M}, title = {Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms}, journal = {Journal of Neuroimmunology}, volume = {262}, number = {1-2}, pages = {106-112}, year = {2013} }
RIS	TY - JOUR AU - Jamshidian A AU - Shaygannejad V AU - Pourazar A AU - Zarkeshesfahani SH AU - Gharagozloo M TI - Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms JO - Journal of Neuroimmunology VL - 262 IS - 1-2 SP - 106 EP - 112 PY - 2013 ER -

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