The Effects of Two Different Doses of Sublingual Sufentanil on Hemodynamic Changes During Laryngoscopy and Tracheal Intubation; [بررسی تأثی ر دو دز مختلف سوفنتانیل زیرزبانی بر تغییرا ت همودینام یک پس از لارنگوسکوپی] Publisher



Honarmand A ; Safavi M ; Sadeghizade S
Source: Journal of Isfahan Medical School Published:2025

Abstract

Background: Hemodynamic disturbance is one of the most challenging complications during laryngoscopy. This study was conducted with the aim of comparing the effect of two doses of 0.1 and 0.2 μg/kg sufentanil on the hemodynamics of patients during and after laryngoscopy. Methods: In this clinical trial study, 96 patients who were candidates for surgery under general anesthesia were divided into three groups of 32. Patients in the first and second groups received 0.1 μg/kg and 0.2 μg/kg of sublingual sufentanil (the sufentanil ampoule was administered sublingually into the oral cavity), respectively, three minutes before the induction of anesthesia. In the third group, normal saline was administered sublingually as a placebo three minutes before anesthesia induction. The patients' hemodynamic parameters were evaluated before laryngoscopy and at 1, 3, 5, and 10 minutes after laryngoscopy, and then compared between the three groups. Findings: Before laryngoscopy, there was no significant difference among the three groups regarding heart rate, blood pressure, or blood oxygen saturation. Changes in systolic, diastolic and mean arterial blood pressure were significantly different between the three groups (P < 0.001) However, the differences in the changes of heart rate (P = 0.059) and blood oxygen saturation percentage (P = 0.237) were not significant among the three groups. Conclusion: The use of 0.2 μg/kg of sublingual sufentanil before laryngoscopy reduce hemodynamic disturbance during and after laryngoscopy, and it seems that the patients who receive this medication dose, have more hemodynamic stability during and after laryngoscopy. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.