Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa

Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa Publisher Pubmed

Sereshki N¹ ; Rafiee M² ; Alipour R¹ ; Rahimyan K³ ; Wilkinson D⁴

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Immunology, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, 9717853577, Iran
3. Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. University of Aberdeen, United Kingdom

Source: BMC Research Notes Published:2023

Abstract

Objective: Sialic acid-binding immunoglobulin-type lectins (Siglecs) are commonly present on immune cells and often mediate cell-to-cell interactions and signaling. Studies have shown the presence of Siglecs 1, 2, 5, 6, 10 and 14 on human spermatozoa. To the best of our knowledge, the expression of CD33 on spermatozoa has not yet been studied. Semen samples were collected from 25 healthy men with normal semen status. CD33 expression on purified spermatozoa was evaluated by flow cytometry methods. Results: The results demonstrate the expression of CD33 on the surface of purified spermatozoa. The mean (± SD) of MFI (mean fluorescence intensity) was 12.85 (± 1.33) and the mean percentage of spermatozoa that express CD33 was 73.75 (± 3.75). Results were obtained showing that spermatozoa express CD33 (or Siglec-3) on their surface. The physiological role of these molecules on spermatozoa remains to be determined. It is recommended that further research be undertaken regarding the role of Siglecs (such as CD33) on spermatozoa apoptosis. © 2023, The Author(s).

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Style	Citing Format
MLA	Sereshki N, et al.. "Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa." BMC Research Notes, vol. 16, no. 1, 2023, pp. -.
APA	Sereshki N, Rafiee M, Alipour R, Rahimyan K, Wilkinson D (2023). Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa. BMC Research Notes, 16(1), -.
Chicago	Sereshki N, Rafiee M, Alipour R, Rahimyan K, Wilkinson D. "Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa." BMC Research Notes 16, no. 1 (2023): -.
Harvard	Sereshki N et al. (2023) 'Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa', BMC Research Notes, 16(1), pp. -.
Vancouver	Sereshki N, Rafiee M, Alipour R, Rahimyan K, Wilkinson D. Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa. BMC Research Notes. 2023;16(1):-.
BibTex	@article{ author = {Sereshki N and Rafiee M and Alipour R and Rahimyan K and Wilkinson D}, title = {Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa}, journal = {BMC Research Notes}, volume = {16}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Sereshki N AU - Rafiee M AU - Alipour R AU - Rahimyan K AU - Wilkinson D TI - Cd33 As a Leukocyte-Associated Marker Expressed on Human Spermatozoa JO - BMC Research Notes VL - 16 IS - 1 SP - EP - PY - 2023 ER -

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