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Preparation, Process Optimization and Characterization of Core-Shell Polyurethane/Chitosan Nanofibers As a Potential Platform for Bioactive Scaffolds Publisher



Maleknia L1 ; Dilamian M2 ; Pilehrood M3 ; Sadeghialiabadi H4 ; Hekmati A5
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran
  2. 2. Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran
  3. 3. Nanotechnology Research Center, Islamic Azad University, South Tehran Branch, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Textile Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran

Source: Research in Pharmaceutical Sciences Published:2018


Abstract

In this paper, polyurethane (PU), chitosan (Cs)/polyethylene oxide (PEO), and core-shell PU/Cs nanofibers were produced at the optimal processing conditions using electrospinning technique. Several methods including SEM, TEM, FTIR, XRD, DSC, TGA and image analysis were utilized to characterize these nanofibrous structures. SEM images exhibited that the core-shell PU/Cs nanofibers were spun without any structural imperfections at the optimized processing conditions. TEM image confirmed the PU/Cs core-shell nanofibers were formed apparently. It that seems the inclusion of Cs/PEO to the shell, did not induce the significant variations in the crystallinity in the core-shell nanofibers. DSC analysis showed that the inclusion of Cs/PEO led to the glass temperature of the composition increased significantly compared to those of neat PU nanofibers. The thermal degradation of core-shell PU/Cs was similar to PU nanofibers degradation due to the higher PU concentration compared to other components. It was hypothesized that the core-shell PU/Cs nanofibers can be used as a potential platform for the bioactive scaffolds in tissue engineering. Further biological tests should be conducted to evaluate this platform as a three dimensional scaffold with the capabilities of releasing the bioactive molecules in a sustained manner. © 2018 Herpetologist's League Inc. All rights reserved.
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