Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response

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Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response Publisher Pubmed

Hombachklonisch S¹ ; Mehrpour M^{2, 3} ; Shojaei S^{1, 4} ; Harlos C^{5, 6} ; Pitz M^{5, 6} ; Hamai A^{2, 3} ; Siemianowicz K⁷ ; Likus W⁸ ; Wiechec E⁹ ; Toyota BD¹⁰ ; Hoshyar R^{11, 12} ; Seyfoori A¹³ ; Sepehri Z^{1, 14} ; Ande SR¹⁵ Show All Authors

Hombachklonisch S¹
Mehrpour M^{2, 3}
Shojaei S^{1, 4}
Harlos C^{5, 6}
Pitz M^{5, 6}
Hamai A^{2, 3}
Siemianowicz K⁷
Likus W⁸
Wiechec E⁹
Toyota BD¹⁰
Hoshyar R^{11, 12}
Seyfoori A¹³
Sepehri Z^{1, 14}
Ande SR¹⁵
Khadem F¹⁶
Akbari M¹³
Gorman AM^{17, 18}
Samali A^{17, 18}
Klonisch T^{1, 6}
Ghavami S^{1, 19}

Source: Pharmacology and Therapeutics Published:2018

Abstract

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15 months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB. © 2017 Elsevier Inc.

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Style	Citing Format
MLA	Hombachklonisch S, et al.. "Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response." Pharmacology and Therapeutics, vol. 184, no. , 2018, pp. 13-41.
APA	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, Hoshyar R, Seyfoori A, Sepehri Z, Ande SR, Khadem F, Akbari M, Gorman AM, Samali A, Klonisch T, Ghavami S (2018). Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response. Pharmacology and Therapeutics, 184(), 13-41.
Chicago	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, et al.. "Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response." Pharmacology and Therapeutics 184, no. (2018): 13-41.
Harvard	Hombachklonisch S et al. (2018) 'Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response', Pharmacology and Therapeutics, 184(), pp. 13-41.
Vancouver	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, et al.. Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response. Pharmacology and Therapeutics. 2018;184():13-41.
BibTex	@article{ author = {Hombachklonisch S and Mehrpour M and Shojaei S and Harlos C and Pitz M and Hamai A and Siemianowicz K and Likus W and Wiechec E and Toyota BD and Hoshyar R and Seyfoori A and Sepehri Z and Ande SR and Khadem F and Akbari M and Gorman AM and Samali A and Klonisch T and Ghavami S}, title = {Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response}, journal = {Pharmacology and Therapeutics}, volume = {184}, number = {}, pages = {13-41}, year = {2018} }
RIS	TY - JOUR AU - Hombachklonisch S AU - Mehrpour M AU - Shojaei S AU - Harlos C AU - Pitz M AU - Hamai A AU - Siemianowicz K AU - Likus W AU - Wiechec E AU - Toyota BD AU - Hoshyar R AU - Seyfoori A AU - Sepehri Z AU - Ande SR AU - Khadem F AU - Akbari M AU - Gorman AM AU - Samali A AU - Klonisch T AU - Ghavami S TI - Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response JO - Pharmacology and Therapeutics VL - 184 IS - SP - 13 EP - 41 PY - 2018 ER -