Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Delivery of Vinblastine-Containing Niosomes Results in Potent in Vitro/In Vivo Cytotoxicity on Tumor Cells Publisher Pubmed



Amiri B1 ; Ahmadvand H1 ; Farhadi A2 ; Najmafshar A3 ; Chiani M4 ; Norouzian D4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Biochemistry Department, Faculty of Medicine, Lorestan University of Medical Science, Khorramabad, Iran
  2. 2. Social Medicine Department, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Clinical Biochemistry Department, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nanobiotechnology Department, Pasteur Institute of Iran, Tehran, Iran

Source: Drug Development and Industrial Pharmacy Published:2018


Abstract

Vinblastine (VB), as a chemotherapeutic agent, is widely used in treatment of different types of cancer. However, its clinical application is limited due to its low water solubility, side effects, and multidrug resistance. The aim of this study was to increase the therapeutic efficacy of VB using drug delivery systems. For this purpose, a PEGylated niosomal formulation of vinblastine (Pn-VB) was prepared by thin film hydration method and physicochemically characterized. Drug release pattern was performed by dialysis diffusion method. The cytotoxicity of Pn-VB was investigated against murine lung cancer TC-1 cells using MTT assay and its tumor inhibitory effect was evaluated in lung tumor-bearing C57BL/6 mice. Mean particle size, zeta potential, entrapment, and loading efficiency of niosomes were obtained to be about 234.3 ± 11.4 nm, -34.6 ± 4.2 mV, 99.92 ± 1.6%, and 2.673 ± 0.30%, respectively. While, the mean particle size and zeta potential for non-PEGylated niosomes were obtained about 212.4 nm and -31.4 mV, respectively. The in vitro release pattern of drug from niosomes showed a sustained release behavior. Pn-VB indicated a significant increase in toxicity against TC-l cells as compared to free VB. In animal model, Pn-VB exhibited stronger tumor inhibitory effect and longer life time in comparison to free VB. In conclusion, Pn-VB showed appropriate stability, high-entrapment efficacy, lower releasing rate, and stronger cytotoxic activity against lung cancer TC-1 cells as compared to free drug. Thus, the Pn-VB could be a promising formulation for delivery of vinblastine to tumor cells with enhanced drug bioavailability and therapeutic efficacy. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
2. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
3. Release Studies on Ciprofloxacin Loaded Non-Ionic Surfactant Vesicles, Avicenna Journal of Medical Biotechnology (2015)
4. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
5. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
6. Gold Nanoparticles Loaded Into Niosomes: A Novel Approach for Enhanced Antitumor Activity Against Human Ovarian Cancer, Advanced Powder Technology (2021)
7. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
8. Ciprofloxacin Nano-Niosomes for Targeting Intracellular Infections: An in Vitro Evaluation, Journal of Nanoparticle Research (2013)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (26)
Farshid Hassanzadeh (14)
Other Related Docs
9. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
10. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
11. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
12. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
13. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
14. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
15. Multifunctional and Stimuli-Responsive Liposomes in Hepatocellular Carcinoma Diagnosis and Therapy, Translational Oncology (2024)
16. Camouflaged Liposomes by 11A4-Nanobody for Co-Delivery of Cisplatin and Nitroxoline in Breast Cancer Tumors: An in Vitro/In Vivo Study, Journal of Drug Delivery Science and Technology (2022)
17. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
18. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
19. Comparing Different Sterol Containing Solid Lipid Nanoparticles for Targeted Delivery of Quercetin in Hepatocellular Carcinoma, Journal of Liposome Research (2014)
20. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
21. Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles As Nanocarriers for Etoposide, Journal of Nanomaterials (2012)
22. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
23. Bentonite Nanoclay-Based Drug-Delivery Systems for Treating Melanoma, Clay Minerals (2018)
24. Ph-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer, ACS Applied Bio Materials (2022)
25. Novel Nanoscale Vanillin Based Covalent Triazine Framework As a Novel Carrier for Sustained Release of Imatinib, Polymers for Advanced Technologies (2023)
26. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
27. Artemisinin (Art) Drug Delivery Using Mixed Non-Ionic Surfactants and Evaluation of Their Efficiency in Different Cancer Cell Lines, International Journal of Drug Delivery Technology (2014)
28. Cytotoxic Effects of Chitosan/Retinoic Acid/Albumin Targeted Nanoparticles Loaded With Doxorubicin on Human Hepatoma Cells, Journal of Isfahan Medical School (2013)
29. Optimisation of Processing Variables Effective on Self-Assembly of Folate Targeted Synpronic-Based Micelles for Docetaxel Delivery in Melanoma Cells, IET Nanobiotechnology (2015)
30. Preparation and Evaluation of Targeted Albumin Lipid Nanoparticles With Lactobionic Acid for Targeted Drug Delivery of Sorafenib in Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2022)
31. Enhancement of Oral Bioavailability of Pentoxifylline by Solid Lipid Nanoparticles, Journal of Liposome Research (2010)
32. Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated With Folic Acid for Treatment of Glioblastoma Multiforma (Gbm), Iranian Journal of Pharmaceutical Research (2020)
33. Pulmonary Delivery of Docetaxel and Celecoxib by Plga Porous Microparticles for Their Synergistic Effects Against Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry (2022)
34. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
35. Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer, Journal of Pharmacy and Pharmaceutical Sciences (2018)
36. Targeted Delivery of Liposomal Ribociclib to Slc7a5 Transporters in Breast Cancer Cells, Investigational New Drugs (2024)
37. Preparation, Characterization, and in Vitro Evaluation of Bleomycin-Containing Nanoliposomes, Chemical Biology and Drug Design (2017)
38. Pegylated Trimethylchitosan Emulsomes Conjugated to Octreotide for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma Cells of Hepg2, Journal of Liposome Research (2019)
39. Polymeric Nanoparticles in Cancer Chemotherapy: A Narrative Review, Iranian Journal of Public Health (2022)
40. In Vitro/In Vivo Evaluation of Agar Nanospheres for Pulmonary Delivery of Bupropion Hcl, Drug Delivery (2016)
41. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
42. Synthesis of Pectin-Deoxycholic Acid Conjugate for Targeted Delivery of Anticancer Drugs in Hepatocellular Carcinoma, International Journal of Biological Macromolecules (2019)
43. Encapsulation of Imatinib in Targeted Kit-5 Nanoparticles for Reducing Its Cardiotoxicity and Hepatotoxicity, Anti-Cancer Agents in Medicinal Chemistry (2020)
44. Niosome As a Drug Carrier for Topical Delivery of N-Acetyl Glucosamine, Research in Pharmaceutical Sciences (2010)
45. Preparation and Characterization of Dry Powder Containing Sunitinib Loaded Phbv Nanoparticles for Enhanced Pulmonary Delivery, Journal of Drug Delivery Science and Technology (2020)
46. Cationic Okra Gum Coated Nanoliposomes As a Ph-Sensitive Carrier for Co-Delivery of Hesperetin and Oxaliplatin in Colorectal Cancers, Pharmaceutical Development and Technology (2022)
47. Nanomedicine for Diagnosis and Treatment of Cancer in Global Market, Journal of Mazandaran University of Medical Sciences (2014)
48. Simvastatin Nanosuspensions Prepared Using a Combination of Ph-Sensitive and Timed-Release Approaches for Potential Treatment of Colorectal Cancer, Pharmaceutical Development and Technology (2021)
49. The Recent Progresses on the Improved Therapy of Melanoma by Novel Drug Delivery Systems, Current Drug Targets (2014)
50. Polyacrylamide-Punicic Acid Conjugate-Based Micelles for Flutamide Delivery in Pc3 Cells of Prostate Cancer: Synthesis, Characterisation and Cytotoxicity Studies, IET Nanobiotechnology (2020)