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Glioblastoma Multiforme: Insights Into Pathogenesis, Key Signaling Pathways, and Therapeutic Strategies Publisher Pubmed

Summary: Study finds targeting key pathways in glioblastoma may improve treatment outcomes. #BrainCancer #Oncology

Pouyan A1 ; Ghorbanlo M2 ; Eslami M3 ; Jahanshahi M4 ; Ziaei E5 ; Salami A6 ; Mokhtari K7 ; Shahpasand K8, 9 ; Farahani N8 ; Meybodi TE10, 11 ; Entezari M8 ; Taheriazam A8, 12 ; Hushmandi K8, 13 ; Hashemi M8
Authors

Source: Molecular Cancer Published:2025


Abstract

Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways, including PI3K/AKT/mTOR, Wnt, NF-κB, and TGF-β, critical to tumor growth, invasion, and treatment resistance. This review examines the epidemiology, molecular mechanisms, and therapeutic prospects of targeting these pathways in GBM, highlighting recent insights into pathway interactions and discovering new therapeutic targets to improve patient outcomes. © The Author(s) 2025.
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