Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial Publisher Pubmed

Summary: Study finds probiotics after gastric bypass improve gut function and metabolic health, but not weight loss. #BariatricSurgery #Probiotics

Melali H¹ ; Abdolahi A² ; Sheikhbahaei E^{1, 3} ; Vakili K⁴ ; Mahmoudieh M¹ ; Keleidari B¹ ; Shahabi S³
Source: Obesity Surgery Published:2024

Abstract

Purpose: Postoperative changes in gut microbiota may occur in patients undergoing Roux-en-Y gastric bypass surgery. In this study, we evaluate the impact of administering probiotic tablets on the gastrointestinal function and metabolic status of these patients. Materials and Methods: This double-blinded randomized clinical trial was conducted from 2021 to 2022 on 135 Roux-en-Y surgery candidates. The intervention group underwent the surgical procedure and started receiving probiotic supplements (Familact Co.) 1 week after surgery; the control group received a placebo. The laboratory and anthropometric data were measured and analyzed before and 3 and 6 months after the intervention. GIQLI questionnaire was also used at the beginning and 6 months after the intervention to evaluate GI symptoms. Results: We observed significantly reduced BMI in both groups after surgeries (P < 0.001). The levels of FBS and HbA1C were significantly lower in the probiotic group compared to the placebo in 3 months (P = 0.02 and P = 0.001, respectively) and 6 months (P < 0.001 for both) after the intervention. The levels of vitamin B12 increased significantly in the probiotic group (P < 0.001), and the values were substantially higher than the placebo group in 3 and 6 months (P < 0.001), respectively. Analysis of the GIQLI questionnaire before and 6 months after interventions also revealed significant improvement in the GIQLI score in both groups (P < 0.001 for probiotics and P = 0.03 for placebo). Conclusion: Probiotic supplement administration following RYGB improves patients’ vitamin and metabolic profile, as well as GI function, although it cannot significantly affect weight loss. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.