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Preparation and Evaluation of Poly Glycerol Sebacate/Poly Hydroxy Butyrate Core-Shell Electrospun Nanofibers With Sequentially Release of Ciprofloxacin and Simvastatin in Wound Dressings Publisher



Heydari P1 ; Varshosaz J2 ; Zargar Kharazi A1 ; Karbasi S1
Authors
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Authors Affiliations
  1. 1. Biomaterials Nanotechnology and Tissue Engineering Faculty, School of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Polymers for Advanced Technologies Published:2018


Abstract

Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60% of ciprofloxacin was released during the first 24 hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2 days. The drug-containing samples showed a proper bactericidal activity against both Gram-positive and Gram-negative bacteria. It may be concluded that the drug-laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration. Copyright © 2018 John Wiley & Sons, Ltd.
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