Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Comparative Analysis of Apc Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry



Dastjerdi MN1 ; Mahmoodi M2
Authors

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues. Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections. Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer. © 2012, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Other Related Docs
7. Ret Protein Expression in Colorectal Cancer; an Immunohistochemical Assessment, Asian Pacific Journal of Cancer Prevention (2021)
16. Gastrointestinal Cancers, Cancer Genetics and Psychotherapy (2017)