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Comparative Analysis of Apc Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry



Dastjerdi MN1 ; Mahmoodi M2
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues. Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections. Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer. © 2012, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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