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Non-Coding Rnas and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders Publisher Pubmed



Yaghoobi Z1, 2 ; Seyed Bagher Nazeri SS3 ; Asadi A4 ; Derafsh E5 ; Talebi Taheri A6 ; Tamtaji Z7 ; Dadgostar E8, 9 ; Rahmatidehkordi F1, 2 ; Aschner M10 ; Mirzaei H11 ; Tamtaji OR1, 2 ; Nabavizadeh F1, 2
Authors
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Authors Affiliations
  1. 1. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Psychiatry and Behavioral Sciences Research Center, School of Medicine, Addiction Institute, and Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Windsor University School of Medicine, Cayon, Saint Kitts and Nevis
  6. 6. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  11. 11. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Source: Neurochemical Research Published:2024


Abstract

Neurological disorders are a major group of non-communicable diseases affecting quality of life. Non-Coding RNAs (ncRNAs) have an important role in the etiology of neurological disorders. In studies on the genesis of neurological diseases, aquaporin 4 (AQP4) expression and activity have both been linked to ncRNAs. The upregulation or downregulation of several ncRNAs leads to neurological disorder progression by targeting AQP4. The role of ncRNAs and AQP4 in neurological disorders is discussed in this review. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
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