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Mechanisms of Apoptosis-Related Non-Coding Rnas in Ovarian Cancer: A Narrative Review Publisher Pubmed



Wang Y1 ; Wang S2 ; He H1 ; Bai Y1 ; Liu Z3 ; Sabihi SS4
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Tang Du Hospital, The Air Force Military Medical University, Xi’an, 710038, China
  2. 2. Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710038, China
  3. 3. Department of Obstetrics and Gynecology, Xi’an International Medical Center Hospital, Xi’an, 710038, China
  4. 4. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Apoptosis Published:2025


Abstract

Ovarian cancer remains a major challenge in oncology due to its complex biology and late-stage diagnosis. Recent advances in molecular biology have highlighted the crucial role of non-coding RNAs (ncRNAs) in regulating apoptosis and cancer progression. NcRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have emerged as significant players in the molecular networks governing ovarian cancer. Despite these insights, the precise mechanisms by which ncRNAs influence ovarian cancer pathology are not fully understood. This complexity, combined with the heterogeneity of the disease and the development of treatment resistance, poses substantial obstacles to effective therapeutic development. Additionally, the lack of reliable early detection methods further complicates treatment strategies. This manuscript reviews the current state of research on ncRNAs in ovarian cancer, discusses the challenges in translating these findings into clinical applications, and outlines potential future directions. Emphasis is placed on the need for integrated approaches to unravel the intricate roles of ncRNAs, improve early detection, and develop personalized treatment strategies to address the diverse and evolving nature of ovarian cancer. While these findings provide valuable insights, it is crucial to recognize that many results are based on preclinical studies and require further validation to establish their clinical applicability. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
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