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Immunodeficiencies Affecting Cellular and Humoral Immunity Publisher



Chavoshzadeh Z1 ; Darougar S2 ; Momen T3 ; Esmaeilzadeh H4 ; Abolhassani H5, 6 ; Cheraghi T7 ; Van Der Burg M8 ; Van Zelm M9
Authors

Source: Inborn Errors of Immunity: A Practical Guide Published:2021


Abstract

Combined immunodeficiencies (CIDs) are the result of defective development or function of T cells. As the most severe form of primary immunodeficiency disorders (PID), CIDs are characterized by a susceptibility to infection, particularly from opportunistic organisms, which leads to severe morbidity and mortality. A subpopulation of patients has additional syndromic features caused by the function of the affected gene beyond the immune system. In this chapter, we will focus on nonsyndromic CIDs. © 2021 Elsevier Inc. All rights reserved.
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