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Role of Micrornas in Pulmonary Hypertension



Rad MR1, 2 ; Zare MM1 ; Shojaei Y1 ; Jamalian M2 ; Izadan M3 ; Dabaghi GG1, 2
Authors
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Authors Affiliations
  1. 1. School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. School of Nursing and Midwifery, Isfahan University of Medical Science, Isfahan, Iran

Source: Horizons in World Cardiovascular Research Published:2022

Abstract

Micro RNAs (miRNAs), small non-coding RNAs, are important parts of cellular communication that can affect numerous biological processes. In recent years, circulating miRNAs have been described as diagnostic tools for several cardiovascular diseases. Changes in the miRNAs levels are related to pulmonary hypertension (PH) via signaling pathways in the pulmonary artery endothelial cell (PAECs) malfunction, pulmonary artery smooth muscle cells (PASMCs) proliferation, and pulmonary arterial adventitial fibroblast (PAAFs) migration. Also, miRNAs contribute to right ventricular dysfunction and systemic angiogenic impairment, which are seen in PH. At the molecular pathways, lung impairment induced by PH is related to ion channels, mitochondrial function, and BMPR2 signaling pathway which all are regulated by miRNAs. This chapter summarizes the role of miRNAs in the development of PH, miRNAs-based therapeutics, and different miRNAs as potential novel biomarkers for the diagnosis of PH. © 2023 by Nova Science Publishers, Inc. All rights reserved.
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