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Association of Gstt1 and Gstm1 Polymorphisms With Blood Pressure: A Bayesian Modeling of Continuous Data



Rafee L1 ; Abedini M2 ; Javanmard SH1 ; Sarrafzadegan N3 ; Mansourian M4
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Statistics and Mathematics, University of Isfahan, Iran
  3. 3. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Biostatistics and Epidemiology Department, Health School, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2014

Abstract

Background: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are a multi-factorial traits and signifi cantly heritable. Glutathione S-transfe rase (GST) enzyme is involved in detoxifi cation of reactive oxygen species. Th e present study aimed at fi nding out the association between GSTM1 and GSTT1 polymorphisms and mean arterial pressure (MAP) in Iranian population. MAP, as the important indicator of blood pressure, is calculated by weighted averaging of SBP and DBP. Materials and Methods: we randomly selected 72 healthy individuals from Isfahan Cohort Study (ICS). Polymerase chain reaction (PCR) was done to detect polymorphism of the GSTM1 and GSTT1 genes. Th e Bayesian Structured Regression model was used, adjusted for sex, age, body mass index (BMI), and smoking status. Results: Th e results showed that both the GSTT1and GSTM1genotypes deletion had a signifi cant effect on MAP increasing in our samples based on 95% Bayesian credible intervals. Conclusion: Th is study demonstrated that GSTT1 and GSTM1 gene increase the arterial pressure; hence, it can predict the susceptibility to cardiovascular disease.
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