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Low Plasma Vitamin D Is Associated With Increased 28-Day Mortality and Worse Clinical Outcomes in Critically Ill Patients Publisher

Summary: A study found low vitamin D in ICU patients links to worse illness and higher death risk. #CriticalCare #VitaminD

Sistanian F1 ; Sedaghat A2 ; Badpeyma M3, 4 ; Rezaiyan MK5 ; Moghaddam AB2 ; Ranjbar G1 ; Arabi M6 ; Bagherniya M7, 8 ; Norouzy A1, 9
Authors

Source: BMC Nutrition Published:2024


Abstract

Background & objective: Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. Materials and methods: In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient’s serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score. Results: A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63–14.27; P = 0.004). Conclusion: The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate. © 2024, The Author(s).
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